Detection of 17a-hydroxyprogesterone caproate in equine plasma by gas chromatography/tandem mass spectrometry
A method was developed for the analysis of the synthetic progestin 17a-hydroxyprogesterone caproate in equine plasma following its administration by intramuscular injection. The method employed a reversed-phase solid-phase extraction followed by enol-trimethylsilylation and analysis by gas chromatog...
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| Veröffentlicht in: | Rapid communications in mass spectrometry 2006-01, Vol.20 (12), p.1855-1858 |
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| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | A method was developed for the analysis of the synthetic progestin 17a-hydroxyprogesterone caproate in equine plasma following its administration by intramuscular injection. The method employed a reversed-phase solid-phase extraction followed by enol-trimethylsilylation and analysis by gas chromatography/tandem mass spectrometry. The intact ester was detectable in the plasma for up to 2 weeks after a single therapeutic dose, and was found to be stable in equine whole blood for at least 2 months. |
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| ISSN: | 0951-4198 1097-0231 |
| DOI: | 10.1002/rcm.2526 |