The Patterning and Alignment of Muscle Cells Using the Selective Adhesion of Poly(oligoethylene glycol methyl ether methacrylate)-based ABA Block Copolymers

The Patterning and Alignment of Muscle Cells Using the Selective Adhesion of Poly(oligoethylene glycol methyl ether methacrylate)-based ABA Block Copolymers

The selective adhesion/delamination behavior of poly(oligoethylene glycol methyl ether methacrylate)‐based ABA block copolymers is exploited to generate patterned substrates consisting of alternating lanes of glass and copolymer‐coated gold. These patterns have been successfully used for the pattern...

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Veröffentlicht in:Advanced materials (Weinheim) 2005-10, Vol.17 (19), p.2324-2329
Hauptverfasser: Popescu, D. C., Lems, R., Rossi, N. A. A., Yeoh, C.-T., Loos, J., Holder, S. J., Bouten, C. V. C., Sommerdijk, N. A. J. M.
Format: Artikel
Sprache:eng
Schlagworte:
Biocompatible materials
Block copolymers
Cells
Patterning
Tissue engineering
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Zusammenfassung:The selective adhesion/delamination behavior of poly(oligoethylene glycol methyl ether methacrylate)‐based ABA block copolymers is exploited to generate patterned substrates consisting of alternating lanes of glass and copolymer‐coated gold. These patterns have been successfully used for the patterning and alignment of C2C12 muscle cells. The parallel‐oriented myotubes (see Figure) contract upon electrical stimulation, forming a promising 2D in‐vitro model for muscles.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.200500039