Dysfunctional adipose tissue and skeletal muscle insulin resistance: Cause and effect or two sides of the same coin?

[...]the correlation between adipose tissue insulin sensitivity (assessed as FA turnover in relation to fat-free mass during the HECP) and skeletal muscle insulin sensitivity (assessed as insulin-stimulated glucose disposal) among all 66 partic-ipants was statistically significant, but weak (r и -0.3). [...]aver-age adipocyte size was only modestly correlated (r и -0.3) with both adipose tissue insulin sensitivity and skeletal muscle insulin sensitivity, and the frequency of large adipocytes was weakly cor-related (r = -0.28) with insulin sensitivity in adipose tissue but not in skeletal muscle. [...]although the glucose disposal rate during the HECP was adjusted for the plasma insulin concentration to evaluate skeletal muscle insulin sensitivity, adipose tissue insulin sensitivity was evaluated without taking into account potential differences in plasma insulin between groups or individuals. [...]adipose tissue insulin sensitivity was evaluated at a near-maximal effective dose of insu-lin on the suppression of adipose tissue triglyceride lipolysis, which reduced the investigators' statistical power to identify relationships.