A Genomic Perspective on the Near-term Impact of Doxycycline Post-exposure Prophylaxis on Neisseria gonorrhoeae Antimicrobial Resistance

Abstract Pre-existing tetracycline resistance in Neisseria gonorrhoeae limits the effectiveness of post-exposure prophylaxis (PEP) with doxycycline against gonorrhea, and selection for tetracycline resistance may influence prevalence of multi-drug resistant strains. Using genomic and antimicrobial s...

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Veröffentlicht in:	Clinical infectious diseases 2023-09, Vol.77 (5), p.788-791
Hauptverfasser:	Mortimer, Tatum D, Grad, Yonatan H
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Doxycycline - pharmacology Doxycycline - therapeutic use Drug Resistance, Bacterial - genetics Genomics Gonorrhea - drug therapy Gonorrhea - epidemiology Gonorrhea - prevention & control Humans Microbial Sensitivity Tests Neisseria gonorrhoeae - genetics Post-Exposure Prophylaxis Tetracycline - pharmacology
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Zusammenfassung:	Abstract Pre-existing tetracycline resistance in Neisseria gonorrhoeae limits the effectiveness of post-exposure prophylaxis (PEP) with doxycycline against gonorrhea, and selection for tetracycline resistance may influence prevalence of multi-drug resistant strains. Using genomic and antimicrobial susceptibility data from N. gonorrhoeae, we assessed the near-term impact of doxycycline PEP on N. gonorrhoeae resistance.
ISSN:	1058-4838 1537-6591
DOI:	10.1093/cid/ciad279