UiO-66-Derived PBA Composite as Multifunctional Electrochemical Non-Enzymatic Sensor Realizing High-Performance Detection of Hydrogen Peroxide and Glucose

In this work, a highly efficient multifunctional non-enzymatic electrochemical sensor is successfully fabricated based on a facile two-step synthetic strategy. It resolves two important challenges of poor stability and low reproducibility compared to conventional electrochemical enzyme-based sensors. Herein, a metal–organic framework (UiO-66) is selected as a sacrificial template to construct the corresponding Prussian blue analogue (PBA) target to improve its stability and conductivity, namely, PBA/UiO-66/NF. Target PBA/UiO-66/NF exhibits excellent electrochemical sensing performance as hydrogen peroxide (H2O2) and glucose sensors with ultrahigh sensitivity of up to 1903 μA mM–1 cm–2 for H2O2 and 22,800 μA mM–1 cm–2 for glucose, as well as a very low detection limit of 0.02 μM (S/N = 3) for H2O2 and 0.28 μM for glucose. Especially, extremely high stability can be observed, which will be beneficial for practical application.