‘On Water’‐Promoted Three‐Component Tandem Michael Addition/D−A Cycloaddition Reaction to Construct Polycyclic N‐Heterocycles Derivatives

‘On Water’‐promoted the three‐component tandem Michael addition/D−A cycloaddition reaction in 80 °C at 3 h has been developed without employing any catalyst and organic solvent. The process allows facile access to polycyclic N‐heterocycles derivatives contain indole and maleimide from easily accessible starting materials in moderate to high yields (up to 91 %). Compared with conventional reaction conditions, this reaction not only improves the reaction efficiency and rate but also minimizes the side reaction. This article reported ‘On Water’‐promoted three‐component tandem Michael addition/D−A cycloaddition reaction of naphthoquinone, indole and maleimide to construct polycyclic N‐heterocycles derivatives in moderate to high yields (up to 91 %) in 80 °C at 3 h.