Evaluation of Nrg4 and thiol/disulfide homeostasis in patients with GDM

Evaluation of Nrg4 and thiol/disulfide homeostasis in patients with GDM

In this study, we aimed to evaluate the role of neuregulin4 (Nrg4) in the etiopathogenesis of gestational diabetes mellitus (GDM) and thiol/disulfide homeostasis as an indicator of oxidative stress. This prospective, case-control study included 34 women with diabetes and 34 healthy pregnant women wh...

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Veröffentlicht in:European journal of obstetrics & gynecology and reproductive biology 2023-06, Vol.285, p.105-109
Hauptverfasser: Cindoglu, Cigdem, Uyanikoglu, Hacer, Esercan, Alev, Eren, Mehmet Ali, Koyuncu, Ismail, Sabuncu, Tevfik
Format: Artikel
Sprache:eng
Schlagworte:
Biomarkers
Case-Control Studies
Diabetes, Gestational
Disulfides
Female
Gestational diabetes mellitus
Homeostasis
Humans
Metabolic disorders
Nrg4
Oxidative Stress
Pregnancy
Prospective Studies
Sulfhydryl Compounds
Thiol/disulfide homeostasis
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Zusammenfassung:In this study, we aimed to evaluate the role of neuregulin4 (Nrg4) in the etiopathogenesis of gestational diabetes mellitus (GDM) and thiol/disulfide homeostasis as an indicator of oxidative stress. This prospective, case-control study included 34 women with diabetes and 34 healthy pregnant women who applied between January 2017 and January 2020. Levels of native and total thiol, disulfide and Nrg4 were measured in both diabetes mellitus and healthy pregnant groups. When compared to the control group, the serum neuregulin4 levels in the diabetes group were considerably lower (3.22 ± 2.16 vs. 4.55 ± 0.96, p 
ISSN:0301-2115
1872-7654
DOI:10.1016/j.ejogrb.2023.04.011