Overexpression of miRNA 26a and 26b with MMP-9 are valuable diagnostic biomarkers for colorectal cancer patients
The key role of miRNA expression in incidence and progression of colorectal cancer (CLC) have been developed over the last decade. A total of 153 subjects were enrolled into two phases: 14 selected miRNAs were first evaluated in 50 subjects, then miR-26a and miR-26b relative expression were further...
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| Veröffentlicht in: | Biomarkers in medicine 2023-02, Vol.17 (3), p.159-169 |
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| container_title | Biomarkers in medicine |
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| creator | Farouk, Sally El-Shenawy, Reem Khairy, Ahmed M Bader El-Din, Noha G |
| description | The key role of miRNA expression in incidence and progression of colorectal cancer (CLC) have been developed over the last decade.
A total of 153 subjects were enrolled into two phases: 14 selected miRNAs were first evaluated in 50 subjects, then miR-26a and miR-26b relative expression were further evaluated in 103 subjects and their target protein MMP-9 was measured.
miR-26a and -26b showed highly significant overexpression. Both miR-26a and -26b (p |
| doi_str_mv | 10.2217/bmm-2022-0861 |
| format | Article |
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A total of 153 subjects were enrolled into two phases: 14 selected miRNAs were first evaluated in 50 subjects, then miR-26a and miR-26b relative expression were further evaluated in 103 subjects and their target protein MMP-9 was measured.
miR-26a and -26b showed highly significant overexpression. Both miR-26a and -26b (p < 0.001) had high diagnostic efficacy for CRC. There was a significant increase in serum MMP-9 protein in CRC patients with positive correlation with miR-26a and -26b expression levels (p < 0.001).
miRNA 26a and 26b with MMP-9 can be used as diagnostic biomarker for CRC patients.
Molecules called miRNAs, found in blood, have a key role in colon cancer progression. This evidence highlights the importance of studying the role of some miRNAs in colorectal cancer (CRC) patients. miRNAs are one of the most recent targets for CRC screening and prognosis. miR-26a and -26b showed high overexpression in CRC patients. Results showed that both miR-26a and -26b had high diagnostic efficacy for CRC.</description><identifier>ISSN: 1752-0363</identifier><identifier>EISSN: 1752-0371</identifier><identifier>DOI: 10.2217/bmm-2022-0861</identifier><identifier>PMID: 37097025</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Biomarkers ; Biomarkers, Tumor - genetics ; colorectal cancer ; Colorectal Neoplasms - diagnosis ; Colorectal Neoplasms - genetics ; diagnostic biomarkers ; Gene Expression Regulation, Neoplastic ; Humans ; Matrix Metalloproteinase 9 - genetics ; Matrix Metalloproteinase 9 - metabolism ; MicroRNAs - genetics ; MicroRNAs - metabolism ; miRNAs ; MMP-9 ; relative expression</subject><ispartof>Biomarkers in medicine, 2023-02, Vol.17 (3), p.159-169</ispartof><rights>2023 Future Medicine Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c343t-30abd0236a1da4b0ec19717f512a3e919f8d286e9d8d460bfba1635e4ba0e0d33</citedby><cites>FETCH-LOGICAL-c343t-30abd0236a1da4b0ec19717f512a3e919f8d286e9d8d460bfba1635e4ba0e0d33</cites><orcidid>0000-0001-8524-1046 ; 0000-0002-3537-2408 ; 0000-0003-2848-6885 ; 0000-0001-7861-238X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37097025$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Farouk, Sally</creatorcontrib><creatorcontrib>El-Shenawy, Reem</creatorcontrib><creatorcontrib>Khairy, Ahmed M</creatorcontrib><creatorcontrib>Bader El-Din, Noha G</creatorcontrib><title>Overexpression of miRNA 26a and 26b with MMP-9 are valuable diagnostic biomarkers for colorectal cancer patients</title><title>Biomarkers in medicine</title><addtitle>Biomark Med</addtitle><description>The key role of miRNA expression in incidence and progression of colorectal cancer (CLC) have been developed over the last decade.
A total of 153 subjects were enrolled into two phases: 14 selected miRNAs were first evaluated in 50 subjects, then miR-26a and miR-26b relative expression were further evaluated in 103 subjects and their target protein MMP-9 was measured.
miR-26a and -26b showed highly significant overexpression. Both miR-26a and -26b (p < 0.001) had high diagnostic efficacy for CRC. There was a significant increase in serum MMP-9 protein in CRC patients with positive correlation with miR-26a and -26b expression levels (p < 0.001).
miRNA 26a and 26b with MMP-9 can be used as diagnostic biomarker for CRC patients.
Molecules called miRNAs, found in blood, have a key role in colon cancer progression. This evidence highlights the importance of studying the role of some miRNAs in colorectal cancer (CRC) patients. miRNAs are one of the most recent targets for CRC screening and prognosis. miR-26a and -26b showed high overexpression in CRC patients. Results showed that both miR-26a and -26b had high diagnostic efficacy for CRC.</description><subject>Biomarkers</subject><subject>Biomarkers, Tumor - genetics</subject><subject>colorectal cancer</subject><subject>Colorectal Neoplasms - diagnosis</subject><subject>Colorectal Neoplasms - genetics</subject><subject>diagnostic biomarkers</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Matrix Metalloproteinase 9 - genetics</subject><subject>Matrix Metalloproteinase 9 - metabolism</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>miRNAs</subject><subject>MMP-9</subject><subject>relative expression</subject><issn>1752-0363</issn><issn>1752-0371</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1P3DAQhi0EYilw7LXykUtaf2zs5IhQoZWgIFTO1tieFNMkTu0E6L_Hq91y62nekZ55pXkI-cjZZyG4_mKHoRJMiIo1iu-RI67rkqXm--9ZyRX5kPMTY7XWShySldSs1UzUR2S6fcaEr1PCnEMcaezoEO5_nFOhgMLoy7T0JcyP9ObmrmopJKTP0C9ge6Q-wK8x5jk4akMcIP3GlGkXE3WxjwndDD11MDpMdII54DjnE3LQQZ_xdDePycPl158X36rr26vvF-fXlZNrOVeSgfVMSAXcw9oydLzVXHc1FyCx5W3XeNEobH3j14rZzgJXssa1BYbMS3lMzra9U4p_FsyzGUJ22PcwYlyyEQ1TTMta6YJWW9SlmHPCzkwplG_-Gs7MRrIpks1GstlILvynXfViB_Tv9D-rBWi3QLfMSzHryucOzXYrF8GFEf9T_gZ1Votp</recordid><startdate>202302</startdate><enddate>202302</enddate><creator>Farouk, Sally</creator><creator>El-Shenawy, Reem</creator><creator>Khairy, Ahmed M</creator><creator>Bader El-Din, Noha G</creator><general>Future Medicine Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8524-1046</orcidid><orcidid>https://orcid.org/0000-0002-3537-2408</orcidid><orcidid>https://orcid.org/0000-0003-2848-6885</orcidid><orcidid>https://orcid.org/0000-0001-7861-238X</orcidid></search><sort><creationdate>202302</creationdate><title>Overexpression of miRNA 26a and 26b with MMP-9 are valuable diagnostic biomarkers for colorectal cancer patients</title><author>Farouk, Sally ; El-Shenawy, Reem ; Khairy, Ahmed M ; Bader El-Din, Noha G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c343t-30abd0236a1da4b0ec19717f512a3e919f8d286e9d8d460bfba1635e4ba0e0d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biomarkers</topic><topic>Biomarkers, Tumor - genetics</topic><topic>colorectal cancer</topic><topic>Colorectal Neoplasms - diagnosis</topic><topic>Colorectal Neoplasms - genetics</topic><topic>diagnostic biomarkers</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Matrix Metalloproteinase 9 - genetics</topic><topic>Matrix Metalloproteinase 9 - metabolism</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>miRNAs</topic><topic>MMP-9</topic><topic>relative expression</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Farouk, Sally</creatorcontrib><creatorcontrib>El-Shenawy, Reem</creatorcontrib><creatorcontrib>Khairy, Ahmed M</creatorcontrib><creatorcontrib>Bader El-Din, Noha G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomarkers in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Farouk, Sally</au><au>El-Shenawy, Reem</au><au>Khairy, Ahmed M</au><au>Bader El-Din, Noha G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Overexpression of miRNA 26a and 26b with MMP-9 are valuable diagnostic biomarkers for colorectal cancer patients</atitle><jtitle>Biomarkers in medicine</jtitle><addtitle>Biomark Med</addtitle><date>2023-02</date><risdate>2023</risdate><volume>17</volume><issue>3</issue><spage>159</spage><epage>169</epage><pages>159-169</pages><issn>1752-0363</issn><eissn>1752-0371</eissn><abstract>The key role of miRNA expression in incidence and progression of colorectal cancer (CLC) have been developed over the last decade.
A total of 153 subjects were enrolled into two phases: 14 selected miRNAs were first evaluated in 50 subjects, then miR-26a and miR-26b relative expression were further evaluated in 103 subjects and their target protein MMP-9 was measured.
miR-26a and -26b showed highly significant overexpression. Both miR-26a and -26b (p < 0.001) had high diagnostic efficacy for CRC. There was a significant increase in serum MMP-9 protein in CRC patients with positive correlation with miR-26a and -26b expression levels (p < 0.001).
miRNA 26a and 26b with MMP-9 can be used as diagnostic biomarker for CRC patients.
Molecules called miRNAs, found in blood, have a key role in colon cancer progression. This evidence highlights the importance of studying the role of some miRNAs in colorectal cancer (CRC) patients. miRNAs are one of the most recent targets for CRC screening and prognosis. miR-26a and -26b showed high overexpression in CRC patients. Results showed that both miR-26a and -26b had high diagnostic efficacy for CRC.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>37097025</pmid><doi>10.2217/bmm-2022-0861</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-8524-1046</orcidid><orcidid>https://orcid.org/0000-0002-3537-2408</orcidid><orcidid>https://orcid.org/0000-0003-2848-6885</orcidid><orcidid>https://orcid.org/0000-0001-7861-238X</orcidid></addata></record> |
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| subjects | Biomarkers Biomarkers, Tumor - genetics colorectal cancer Colorectal Neoplasms - diagnosis Colorectal Neoplasms - genetics diagnostic biomarkers Gene Expression Regulation, Neoplastic Humans Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism MicroRNAs - genetics MicroRNAs - metabolism miRNAs MMP-9 relative expression |
| title | Overexpression of miRNA 26a and 26b with MMP-9 are valuable diagnostic biomarkers for colorectal cancer patients |
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