Overexpression of miRNA 26a and 26b with MMP-9 are valuable diagnostic biomarkers for colorectal cancer patients

The key role of miRNA expression in incidence and progression of colorectal cancer (CLC) have been developed over the last decade. A total of 153 subjects were enrolled into two phases: 14 selected miRNAs were first evaluated in 50 subjects, then miR-26a and miR-26b relative expression were further...

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Veröffentlicht in:	Biomarkers in medicine 2023-02, Vol.17 (3), p.159-169
Hauptverfasser:	Farouk, Sally, El-Shenawy, Reem, Khairy, Ahmed M, Bader El-Din, Noha G
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Biomarkers, Tumor - genetics colorectal cancer Colorectal Neoplasms - diagnosis Colorectal Neoplasms - genetics diagnostic biomarkers Gene Expression Regulation, Neoplastic Humans Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism MicroRNAs - genetics MicroRNAs - metabolism miRNAs MMP-9 relative expression
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Zusammenfassung:	The key role of miRNA expression in incidence and progression of colorectal cancer (CLC) have been developed over the last decade. A total of 153 subjects were enrolled into two phases: 14 selected miRNAs were first evaluated in 50 subjects, then miR-26a and miR-26b relative expression were further evaluated in 103 subjects and their target protein MMP-9 was measured. miR-26a and -26b showed highly significant overexpression. Both miR-26a and -26b (p
ISSN:	1752-0363 1752-0371
DOI:	10.2217/bmm-2022-0861