Effects of Burosumab Treatment on Mineral Metabolism in Children and Adolescents With X-linked Hypophosphatemia

Effects of Burosumab Treatment on Mineral Metabolism in Children and Adolescents With X-linked Hypophosphatemia

Abstract Context Burosumab has been approved for the treatment of children and adults with X-linked hypophosphatemia (XLH). Real-world data and evidence for its efficacy in adolescents are lacking. Objective To assess the effects of 12 months of burosumab treatment on mineral metabolism in children...

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Veröffentlicht in:The journal of clinical endocrinology and metabolism 2023-09, Vol.108 (10), p.e998-e1006
Hauptverfasser: Ewert, Annika, Rehberg, Mirko, Schlingmann, Karl Peter, Hiort, Olaf, John-Kroegel, Ulrike, Metzing, Oliver, Wühl, Elke, Schaefer, Franz, Kemper, Markus J, Derichs, Ute, Richter-Unruh, Annette, Patzer, Ludwig, Albers, Norbert, Dunstheimer, Desiree, Haberland, Holger, Heger, Sabine, Schröder, Carmen, Jorch, Norbert, Schmid, Elmar, Staude, Hagen, Weitz, Marcus, Freiberg, Clemens, Leifheit-Nestler, Maren, Zivicnjak, Miroslav, Schnabel, Dirk, Haffner, Dieter
Format: Artikel
Sprache:eng
Schlagworte:
Adolescents
Age
Alkaline phosphatase
Children
Glomerular filtration rate
Hypophosphatemia
Metabolism
Monoclonal antibodies
Patients
Phosphate
Reabsorption
Rickets
Teenagers
Vitamin D
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Zusammenfassung:Abstract Context Burosumab has been approved for the treatment of children and adults with X-linked hypophosphatemia (XLH). Real-world data and evidence for its efficacy in adolescents are lacking. Objective To assess the effects of 12 months of burosumab treatment on mineral metabolism in children (aged
ISSN:0021-972X
1945-7197
DOI:10.1210/clinem/dgad223