Expanding therapeutic potential of Bdellovibrio bacteriovorus against multidrug-resistant pathogens
•Resistant-bacterial infections are one of the main health problems in the world.•Predatory bacteria could be a new therapy against resistant bacteria.•Combination therapy with Bdellovibrio bacteriovorus can lead to better activity against pathogenic bacteria.•Anti-virulence compounds combined with...
Gespeichert in:
| Veröffentlicht in: | Drug discovery today 2023-06, Vol.28 (6), p.103595-103595, Article 103595 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 103595 |
|---|---|
| container_issue | 6 |
| container_start_page | 103595 |
| container_title | Drug discovery today |
| container_volume | 28 |
| creator | Maurmann de Souza, Camila Fleitas Martínez, Osmel Morales Duque, Harry Franco, Octávio Luiz |
| description | •Resistant-bacterial infections are one of the main health problems in the world.•Predatory bacteria could be a new therapy against resistant bacteria.•Combination therapy with Bdellovibrio bacteriovorus can lead to better activity against pathogenic bacteria.•Anti-virulence compounds combined with Bdellovibrio bacteriovorus could be a new type of treatment.
Novel treatments toward Gram-negative bacteria are urgently needed to prevent even higher mortality levels associated with resistant bacterial infections. Predatory bacteria have been studied as a new type of treatment against pathogenic bacteria, including resistant species. However, because of limitations related to eradication efficacy, combination therapy using predatory bacteria with other agents has also been tested. Here, we discuss recent advances in the use of predatory bacteria to treat infections and propose novel combinatory strategies with antivirulence compounds. |
| doi_str_mv | 10.1016/j.drudis.2023.103595 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2805517248</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1359644623001113</els_id><sourcerecordid>2805517248</sourcerecordid><originalsourceid>FETCH-LOGICAL-c311t-aa3fedcad8a6d35446fb79edfb761067070930debda0e5ea2184179905e579003</originalsourceid><addsrcrecordid>eNp9kE1LxDAQhoMofv8DkR69dE2apk0vgsr6AYIXPYdpMl2zdJuapIv-eyNVj15mhuGdmXceQs4YXTDKqsv1wvjJ2LAoaMFTi4tG7JBDJmuZC8mL3VSnXl6VZXVAjkJYU8qKRlT75IDXVEouqkOilx8jDMYOqyy-oYcRp2h1NrqIQ7TQZ67Lbgz2vdva1luXtaAjpmLr_BQyWIEdQsw2Ux9t8rPKPQYbIgwxGyG-uRUO4YTsddAHPP3Jx-T1bvly-5A_Pd8_3l4_5ZozFnMA3qHRYCRUhotku2vrBk2KFaNVTWvacGqwNUBRIBRMlqxuGipQ1A2l_JhczHtH794nDFFtbNDJOwzopqAKSYVgdVHKJC1nqfYuBI-dGr3dgP9UjKpvvGqtZrzqG6-a8aax858LU7tB8zf0yzMJrmYBpj-3Fr0K2uKg0ViPOirj7P8XvgBMOZBZ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2805517248</pqid></control><display><type>article</type><title>Expanding therapeutic potential of Bdellovibrio bacteriovorus against multidrug-resistant pathogens</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Maurmann de Souza, Camila ; Fleitas Martínez, Osmel ; Morales Duque, Harry ; Franco, Octávio Luiz</creator><creatorcontrib>Maurmann de Souza, Camila ; Fleitas Martínez, Osmel ; Morales Duque, Harry ; Franco, Octávio Luiz</creatorcontrib><description>•Resistant-bacterial infections are one of the main health problems in the world.•Predatory bacteria could be a new therapy against resistant bacteria.•Combination therapy with Bdellovibrio bacteriovorus can lead to better activity against pathogenic bacteria.•Anti-virulence compounds combined with Bdellovibrio bacteriovorus could be a new type of treatment.
Novel treatments toward Gram-negative bacteria are urgently needed to prevent even higher mortality levels associated with resistant bacterial infections. Predatory bacteria have been studied as a new type of treatment against pathogenic bacteria, including resistant species. However, because of limitations related to eradication efficacy, combination therapy using predatory bacteria with other agents has also been tested. Here, we discuss recent advances in the use of predatory bacteria to treat infections and propose novel combinatory strategies with antivirulence compounds.</description><identifier>ISSN: 1359-6446</identifier><identifier>EISSN: 1878-5832</identifier><identifier>DOI: 10.1016/j.drudis.2023.103595</identifier><identifier>PMID: 37088356</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>bacteria ; Bdellovibrio bacteriovorus ; Gram-Negative Bacteria ; predation ; quorum quenching ; resistance ; therapy</subject><ispartof>Drug discovery today, 2023-06, Vol.28 (6), p.103595-103595, Article 103595</ispartof><rights>2023 Elsevier Ltd</rights><rights>Copyright © 2023 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c311t-aa3fedcad8a6d35446fb79edfb761067070930debda0e5ea2184179905e579003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1359644623001113$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37088356$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maurmann de Souza, Camila</creatorcontrib><creatorcontrib>Fleitas Martínez, Osmel</creatorcontrib><creatorcontrib>Morales Duque, Harry</creatorcontrib><creatorcontrib>Franco, Octávio Luiz</creatorcontrib><title>Expanding therapeutic potential of Bdellovibrio bacteriovorus against multidrug-resistant pathogens</title><title>Drug discovery today</title><addtitle>Drug Discov Today</addtitle><description>•Resistant-bacterial infections are one of the main health problems in the world.•Predatory bacteria could be a new therapy against resistant bacteria.•Combination therapy with Bdellovibrio bacteriovorus can lead to better activity against pathogenic bacteria.•Anti-virulence compounds combined with Bdellovibrio bacteriovorus could be a new type of treatment.
Novel treatments toward Gram-negative bacteria are urgently needed to prevent even higher mortality levels associated with resistant bacterial infections. Predatory bacteria have been studied as a new type of treatment against pathogenic bacteria, including resistant species. However, because of limitations related to eradication efficacy, combination therapy using predatory bacteria with other agents has also been tested. Here, we discuss recent advances in the use of predatory bacteria to treat infections and propose novel combinatory strategies with antivirulence compounds.</description><subject>bacteria</subject><subject>Bdellovibrio bacteriovorus</subject><subject>Gram-Negative Bacteria</subject><subject>predation</subject><subject>quorum quenching</subject><subject>resistance</subject><subject>therapy</subject><issn>1359-6446</issn><issn>1878-5832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMofv8DkR69dE2apk0vgsr6AYIXPYdpMl2zdJuapIv-eyNVj15mhuGdmXceQs4YXTDKqsv1wvjJ2LAoaMFTi4tG7JBDJmuZC8mL3VSnXl6VZXVAjkJYU8qKRlT75IDXVEouqkOilx8jDMYOqyy-oYcRp2h1NrqIQ7TQZ67Lbgz2vdva1luXtaAjpmLr_BQyWIEdQsw2Ux9t8rPKPQYbIgwxGyG-uRUO4YTsddAHPP3Jx-T1bvly-5A_Pd8_3l4_5ZozFnMA3qHRYCRUhotku2vrBk2KFaNVTWvacGqwNUBRIBRMlqxuGipQ1A2l_JhczHtH794nDFFtbNDJOwzopqAKSYVgdVHKJC1nqfYuBI-dGr3dgP9UjKpvvGqtZrzqG6-a8aax858LU7tB8zf0yzMJrmYBpj-3Fr0K2uKg0ViPOirj7P8XvgBMOZBZ</recordid><startdate>202306</startdate><enddate>202306</enddate><creator>Maurmann de Souza, Camila</creator><creator>Fleitas Martínez, Osmel</creator><creator>Morales Duque, Harry</creator><creator>Franco, Octávio Luiz</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202306</creationdate><title>Expanding therapeutic potential of Bdellovibrio bacteriovorus against multidrug-resistant pathogens</title><author>Maurmann de Souza, Camila ; Fleitas Martínez, Osmel ; Morales Duque, Harry ; Franco, Octávio Luiz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-aa3fedcad8a6d35446fb79edfb761067070930debda0e5ea2184179905e579003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>bacteria</topic><topic>Bdellovibrio bacteriovorus</topic><topic>Gram-Negative Bacteria</topic><topic>predation</topic><topic>quorum quenching</topic><topic>resistance</topic><topic>therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maurmann de Souza, Camila</creatorcontrib><creatorcontrib>Fleitas Martínez, Osmel</creatorcontrib><creatorcontrib>Morales Duque, Harry</creatorcontrib><creatorcontrib>Franco, Octávio Luiz</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Drug discovery today</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maurmann de Souza, Camila</au><au>Fleitas Martínez, Osmel</au><au>Morales Duque, Harry</au><au>Franco, Octávio Luiz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expanding therapeutic potential of Bdellovibrio bacteriovorus against multidrug-resistant pathogens</atitle><jtitle>Drug discovery today</jtitle><addtitle>Drug Discov Today</addtitle><date>2023-06</date><risdate>2023</risdate><volume>28</volume><issue>6</issue><spage>103595</spage><epage>103595</epage><pages>103595-103595</pages><artnum>103595</artnum><issn>1359-6446</issn><eissn>1878-5832</eissn><abstract>•Resistant-bacterial infections are one of the main health problems in the world.•Predatory bacteria could be a new therapy against resistant bacteria.•Combination therapy with Bdellovibrio bacteriovorus can lead to better activity against pathogenic bacteria.•Anti-virulence compounds combined with Bdellovibrio bacteriovorus could be a new type of treatment.
Novel treatments toward Gram-negative bacteria are urgently needed to prevent even higher mortality levels associated with resistant bacterial infections. Predatory bacteria have been studied as a new type of treatment against pathogenic bacteria, including resistant species. However, because of limitations related to eradication efficacy, combination therapy using predatory bacteria with other agents has also been tested. Here, we discuss recent advances in the use of predatory bacteria to treat infections and propose novel combinatory strategies with antivirulence compounds.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>37088356</pmid><doi>10.1016/j.drudis.2023.103595</doi><tpages>1</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1359-6446 |
| ispartof | Drug discovery today, 2023-06, Vol.28 (6), p.103595-103595, Article 103595 |
| issn | 1359-6446 1878-5832 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2805517248 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | bacteria Bdellovibrio bacteriovorus Gram-Negative Bacteria predation quorum quenching resistance therapy |
| title | Expanding therapeutic potential of Bdellovibrio bacteriovorus against multidrug-resistant pathogens |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T12%3A54%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Expanding%20therapeutic%20potential%20of%20Bdellovibrio%20bacteriovorus%20against%20multidrug-resistant%20pathogens&rft.jtitle=Drug%20discovery%20today&rft.au=Maurmann%20de%20Souza,%20Camila&rft.date=2023-06&rft.volume=28&rft.issue=6&rft.spage=103595&rft.epage=103595&rft.pages=103595-103595&rft.artnum=103595&rft.issn=1359-6446&rft.eissn=1878-5832&rft_id=info:doi/10.1016/j.drudis.2023.103595&rft_dat=%3Cproquest_cross%3E2805517248%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2805517248&rft_id=info:pmid/37088356&rft_els_id=S1359644623001113&rfr_iscdi=true |