Expanding therapeutic potential of Bdellovibrio bacteriovorus against multidrug-resistant pathogens

•Resistant-bacterial infections are one of the main health problems in the world.•Predatory bacteria could be a new therapy against resistant bacteria.•Combination therapy with Bdellovibrio bacteriovorus can lead to better activity against pathogenic bacteria.•Anti-virulence compounds combined with Bdellovibrio bacteriovorus could be a new type of treatment. Novel treatments toward Gram-negative bacteria are urgently needed to prevent even higher mortality levels associated with resistant bacterial infections. Predatory bacteria have been studied as a new type of treatment against pathogenic bacteria, including resistant species. However, because of limitations related to eradication efficacy, combination therapy using predatory bacteria with other agents has also been tested. Here, we discuss recent advances in the use of predatory bacteria to treat infections and propose novel combinatory strategies with antivirulence compounds.