Deorphanizing Peptides Using Structure Prediction

Many endogenous peptides rely on signaling pathways to exert their function, but identifying their cognate receptors remains a challenging problem. We investigate the use of AlphaFold-Multimer complex structure prediction together with transmembrane topology prediction for peptide deorphanization. W...

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Veröffentlicht in:	Journal of chemical information and modeling 2023-05, Vol.63 (9), p.2651-2655
Hauptverfasser:	Teufel, Felix, Refsgaard, Jan C., Kasimova, Marina A., Deibler, Kristine, Madsen, Christian T., Stahlhut, Carsten, Grønborg, Mads, Winther, Ole, Madsen, Dennis
Format:	Artikel
Sprache:	eng
Schlagworte:	Humans Peptides Peptides - metabolism Receptors Signal Transduction Topology
Online-Zugang:	Volltext
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