Immunology Insulin auto-antigenicity in type 1 diabetes (Reply)

Immunology Insulin auto-antigenicity in type 1 diabetes (Reply)

Wilson discusses the avidity of the lymph-node T-cell clones we described that recognize the insulin A1-15 fragment. He questions whether large enough concentrations of insulin would be available in situ for antigenic stimulation of T cells, given the amount of peptide required to stimulate the clon...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nature 2005-11, Vol.438 (7067), p.E5-E6
Hauptverfasser: Hafler, David A, Kent, Sally C, Chen, Yahua, Bregoli, Lisa, Clemmings, Sue M, Hering, Bernhard, Kenyon, Norma Sue, Ricordi, Camillo
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Wilson discusses the avidity of the lymph-node T-cell clones we described that recognize the insulin A1-15 fragment. He questions whether large enough concentrations of insulin would be available in situ for antigenic stimulation of T cells, given the amount of peptide required to stimulate the clones and their degree of responsiveness.
ISSN:0028-0836
1476-4687
1476-4679
DOI:10.1038/nature04424