Develop adult extrapolation to pediatrics and pediatric dose optimization based on the physiological pharmacokinetic model of azithromycin

Develop adult extrapolation to pediatrics and pediatric dose optimization based on the physiological pharmacokinetic model of azithromycin

Physiologically‐based pharmacokinetic (PBPK) models are more frequently used for supporting pediatric dose selection in small‐molecule drugs. Through literature research, drug parameters of azithromycin and clinical data from different studies were obtained. Through parameter optimization of the abs...

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Veröffentlicht in:Biopharmaceutics & drug disposition 2023-06, Vol.44 (3), p.245-258
Hauptverfasser: Liang, Luhua, Li, Wentao, Zhang, Zhihao, Li, Dingyuan, Pu, Sijing, Xiang, Rongwu, Zhai, Fei
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Adults
adult–child model transformation
Azithromycin
Child
Child, Preschool
Computer Simulation
Dosage
dose optimization
Humans
Infant, Newborn
Intravenous administration
Models, Biological
PBPK
Pediatrics
Pharmacodynamics
Pharmacokinetics
PK/PD
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Zusammenfassung:Physiologically‐based pharmacokinetic (PBPK) models are more frequently used for supporting pediatric dose selection in small‐molecule drugs. Through literature research, drug parameters of azithromycin and clinical data from different studies were obtained. Through parameter optimization of the absorption and dissolution process, the adult intravenous model was extended to the adult oral model. The adult intravenous and oral PBPK models are precise to meet the AAFE
ISSN:0142-2782
1099-081X
DOI:10.1002/bdd.2352