Placental lesions associated with stillbirth by gestational age, according to feature importance: Results from the stillbirth collaborative research network
Previous studies have identified lesions commonly found in placentas associated with stillbirth but have not distinguished across a range of gestational ages (GAs). The objective of this study was to identify lesions associated with stillbirths at different GAs by adapting methods from the chemical...
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| Veröffentlicht in: | Placenta (Eastbourne) 2023-06, Vol.137, p.59-64 |
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| creator | Cersonsky, Tess E.K. Cersonsky, Rose K. Saade, George R. Silver, Robert M. Reddy, Uma M. Goldenberg, Robert L. Dudley, Donald J. Pinar, Halit |
| description | Previous studies have identified lesions commonly found in placentas associated with stillbirth but have not distinguished across a range of gestational ages (GAs). The objective of this study was to identify lesions associated with stillbirths at different GAs by adapting methods from the chemical machine learning field to assign lesion importance based on correlation with GA.
Placentas from the Stillbirth Collaborative Research Network were examined according to standard protocols. GAs at stillbirth were categorized as: |
| doi_str_mv | 10.1016/j.placenta.2023.04.005 |
| format | Article |
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Placentas from the Stillbirth Collaborative Research Network were examined according to standard protocols. GAs at stillbirth were categorized as: <28 weeks (extreme preterm stillbirth [PTSB]), 28–33′6 weeks (early PTSB), 34–36′6 weeks (late PTSB), ≥37 weeks (term stillbirth). We identified and ranked the most discriminating placental features, as well as those that were similar across GA ranges, using Kernel Principal Covariates Regression (KPCovR).
These analyses included 210 (47.2%) extreme PTSB, 85 (19.1%) early PTSB, 62 (13.9%) late PTSB, and 88 (19.8%) term stillbirths. When we compute the KPCovR, the first principal covariate indicates that there are four lesions (acute funisitis & nucleated fetal red blood cells found in extreme PTSB; multifocal reactive amniocytes & multifocal meconium found in term stillbirth) that distinguish GA ranges among all stillbirths.
There are distinct placental lesions present across GA ranges in stillbirths; these lesions are identifiable using sophisticated feature selection. Further investigation may identify histologic changes across gestations that relate to fetal mortality.
•SCRN contains comprehensive placental examination data for stillbirths.•Lesions are found in association with stillbirth at different gestational ages.oFunisitis and nucleated fetal red cells are found in extreme preterm stillbirth.oMultifocal reactive amniocytes and meconium are found in term stillbirth.•Kernel Principal Covariates Regression can delineate placental features.</description><identifier>ISSN: 0143-4004</identifier><identifier>EISSN: 1532-3102</identifier><identifier>DOI: 10.1016/j.placenta.2023.04.005</identifier><identifier>PMID: 37080046</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Feature selection ; Female ; Gestational Age ; Humans ; Infant, Newborn ; Intrauterine fetal demise ; Kernel principal covariates regression ; Placenta - pathology ; Placenta Diseases - pathology ; Placental lesions ; Pregnancy ; Pregnancy Complications - pathology ; Stillbirth</subject><ispartof>Placenta (Eastbourne), 2023-06, Vol.137, p.59-64</ispartof><rights>2023 Elsevier Ltd</rights><rights>Copyright © 2023 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-d0b920f16f28b0c20fbb3086df8946a4b0de5bb4a754dace1600ab4b41159b583</citedby><cites>FETCH-LOGICAL-c368t-d0b920f16f28b0c20fbb3086df8946a4b0de5bb4a754dace1600ab4b41159b583</cites><orcidid>0000-0002-9539-1408</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.placenta.2023.04.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37080046$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cersonsky, Tess E.K.</creatorcontrib><creatorcontrib>Cersonsky, Rose K.</creatorcontrib><creatorcontrib>Saade, George R.</creatorcontrib><creatorcontrib>Silver, Robert M.</creatorcontrib><creatorcontrib>Reddy, Uma M.</creatorcontrib><creatorcontrib>Goldenberg, Robert L.</creatorcontrib><creatorcontrib>Dudley, Donald J.</creatorcontrib><creatorcontrib>Pinar, Halit</creatorcontrib><title>Placental lesions associated with stillbirth by gestational age, according to feature importance: Results from the stillbirth collaborative research network</title><title>Placenta (Eastbourne)</title><addtitle>Placenta</addtitle><description>Previous studies have identified lesions commonly found in placentas associated with stillbirth but have not distinguished across a range of gestational ages (GAs). The objective of this study was to identify lesions associated with stillbirths at different GAs by adapting methods from the chemical machine learning field to assign lesion importance based on correlation with GA.
Placentas from the Stillbirth Collaborative Research Network were examined according to standard protocols. GAs at stillbirth were categorized as: <28 weeks (extreme preterm stillbirth [PTSB]), 28–33′6 weeks (early PTSB), 34–36′6 weeks (late PTSB), ≥37 weeks (term stillbirth). We identified and ranked the most discriminating placental features, as well as those that were similar across GA ranges, using Kernel Principal Covariates Regression (KPCovR).
These analyses included 210 (47.2%) extreme PTSB, 85 (19.1%) early PTSB, 62 (13.9%) late PTSB, and 88 (19.8%) term stillbirths. When we compute the KPCovR, the first principal covariate indicates that there are four lesions (acute funisitis & nucleated fetal red blood cells found in extreme PTSB; multifocal reactive amniocytes & multifocal meconium found in term stillbirth) that distinguish GA ranges among all stillbirths.
There are distinct placental lesions present across GA ranges in stillbirths; these lesions are identifiable using sophisticated feature selection. Further investigation may identify histologic changes across gestations that relate to fetal mortality.
•SCRN contains comprehensive placental examination data for stillbirths.•Lesions are found in association with stillbirth at different gestational ages.oFunisitis and nucleated fetal red cells are found in extreme preterm stillbirth.oMultifocal reactive amniocytes and meconium are found in term stillbirth.•Kernel Principal Covariates Regression can delineate placental features.</description><subject>Feature selection</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Intrauterine fetal demise</subject><subject>Kernel principal covariates regression</subject><subject>Placenta - pathology</subject><subject>Placenta Diseases - pathology</subject><subject>Placental lesions</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - pathology</subject><subject>Stillbirth</subject><issn>0143-4004</issn><issn>1532-3102</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhS1URIfCK1ResmjCteOkCatWVQtIlUAI1pZ_bmY8OPHUdlr1XXhYXM20YsfKV9Y55_r4I-SUQc2AdR-39c4rg3NWNQfe1CBqgPYVWbG24VXDgB-RFTDRVAJAHJO3KW0BYBCMvyHHzTn05bpbkT_fDzGeekwuzImqlIJxKqOlDy5vaMrOe-1iGfUjXWPKKhdhcag1nlFlTIjWzWuaAx1R5SUiddMuxKxmg5_oD0yLz4mOMUw0b_DfQBO8VzrEkniPNGJCFc2GzpgfQvz9jrwelU_4_nCekF831z-vvlS33z5_vbq8rUzT9bmyoAcOI-tG3mswZdS6gb6zYz-ITgkNFluthTpvhS1tWQegtNCCsXbQbd-ckA_73F0Md0spKCeXDJanzRiWJHkPLfCh5axIu73UxJBSxFHuoptUfJQM5BMZuZXPZOQTGQlCFjLFeHrYsegJ7YvtGUURXOwFWJreO4wyGYflB62LaLK0wf1vx1-zGKdx</recordid><startdate>202306</startdate><enddate>202306</enddate><creator>Cersonsky, Tess E.K.</creator><creator>Cersonsky, Rose K.</creator><creator>Saade, George R.</creator><creator>Silver, Robert M.</creator><creator>Reddy, Uma M.</creator><creator>Goldenberg, Robert L.</creator><creator>Dudley, Donald J.</creator><creator>Pinar, Halit</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9539-1408</orcidid></search><sort><creationdate>202306</creationdate><title>Placental lesions associated with stillbirth by gestational age, according to feature importance: Results from the stillbirth collaborative research network</title><author>Cersonsky, Tess E.K. ; Cersonsky, Rose K. ; Saade, George R. ; Silver, Robert M. ; Reddy, Uma M. ; Goldenberg, Robert L. ; Dudley, Donald J. ; Pinar, Halit</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-d0b920f16f28b0c20fbb3086df8946a4b0de5bb4a754dace1600ab4b41159b583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Feature selection</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Intrauterine fetal demise</topic><topic>Kernel principal covariates regression</topic><topic>Placenta - pathology</topic><topic>Placenta Diseases - pathology</topic><topic>Placental lesions</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - pathology</topic><topic>Stillbirth</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cersonsky, Tess E.K.</creatorcontrib><creatorcontrib>Cersonsky, Rose K.</creatorcontrib><creatorcontrib>Saade, George R.</creatorcontrib><creatorcontrib>Silver, Robert M.</creatorcontrib><creatorcontrib>Reddy, Uma M.</creatorcontrib><creatorcontrib>Goldenberg, Robert L.</creatorcontrib><creatorcontrib>Dudley, Donald J.</creatorcontrib><creatorcontrib>Pinar, Halit</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Placenta (Eastbourne)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cersonsky, Tess E.K.</au><au>Cersonsky, Rose K.</au><au>Saade, George R.</au><au>Silver, Robert M.</au><au>Reddy, Uma M.</au><au>Goldenberg, Robert L.</au><au>Dudley, Donald J.</au><au>Pinar, Halit</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Placental lesions associated with stillbirth by gestational age, according to feature importance: Results from the stillbirth collaborative research network</atitle><jtitle>Placenta (Eastbourne)</jtitle><addtitle>Placenta</addtitle><date>2023-06</date><risdate>2023</risdate><volume>137</volume><spage>59</spage><epage>64</epage><pages>59-64</pages><issn>0143-4004</issn><eissn>1532-3102</eissn><abstract>Previous studies have identified lesions commonly found in placentas associated with stillbirth but have not distinguished across a range of gestational ages (GAs). The objective of this study was to identify lesions associated with stillbirths at different GAs by adapting methods from the chemical machine learning field to assign lesion importance based on correlation with GA.
Placentas from the Stillbirth Collaborative Research Network were examined according to standard protocols. GAs at stillbirth were categorized as: <28 weeks (extreme preterm stillbirth [PTSB]), 28–33′6 weeks (early PTSB), 34–36′6 weeks (late PTSB), ≥37 weeks (term stillbirth). We identified and ranked the most discriminating placental features, as well as those that were similar across GA ranges, using Kernel Principal Covariates Regression (KPCovR).
These analyses included 210 (47.2%) extreme PTSB, 85 (19.1%) early PTSB, 62 (13.9%) late PTSB, and 88 (19.8%) term stillbirths. When we compute the KPCovR, the first principal covariate indicates that there are four lesions (acute funisitis & nucleated fetal red blood cells found in extreme PTSB; multifocal reactive amniocytes & multifocal meconium found in term stillbirth) that distinguish GA ranges among all stillbirths.
There are distinct placental lesions present across GA ranges in stillbirths; these lesions are identifiable using sophisticated feature selection. Further investigation may identify histologic changes across gestations that relate to fetal mortality.
•SCRN contains comprehensive placental examination data for stillbirths.•Lesions are found in association with stillbirth at different gestational ages.oFunisitis and nucleated fetal red cells are found in extreme preterm stillbirth.oMultifocal reactive amniocytes and meconium are found in term stillbirth.•Kernel Principal Covariates Regression can delineate placental features.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>37080046</pmid><doi>10.1016/j.placenta.2023.04.005</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-9539-1408</orcidid></addata></record> |
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| ispartof | Placenta (Eastbourne), 2023-06, Vol.137, p.59-64 |
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| subjects | Feature selection Female Gestational Age Humans Infant, Newborn Intrauterine fetal demise Kernel principal covariates regression Placenta - pathology Placenta Diseases - pathology Placental lesions Pregnancy Pregnancy Complications - pathology Stillbirth |
| title | Placental lesions associated with stillbirth by gestational age, according to feature importance: Results from the stillbirth collaborative research network |
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