Cell Cycle-Related FAM64A Could be Activated by TGF-β Signaling to Promote Glioma Progression

Cell Cycle-Related FAM64A Could be Activated by TGF-β Signaling to Promote Glioma Progression

Gliomas are aggressive brain tumors characterized by uncontrolled cell proliferation. FAM64A, a cell cycle-related gene, has been found to promote cell proliferation in various tumors, including gliomas. However, the regulatory mechanism and clinical significance of FAM64A in gliomas remain unclear....

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Veröffentlicht in:Cellular and molecular neurobiology 2023-08, Vol.43 (6), p.2975-2987
Hauptverfasser: Fu, Minjie, Zhang, Jingwen, Zhang, Licheng, Feng, Yuan, Fang, Xinqi, Zhang, Jinsen, Wen, Wenyu, Hua, Wei, Mao, Ying
Format: Artikel
Sprache:eng
Schlagworte:
Biomedical and Life Sciences
Biomedicine
Brain cancer
Brain tumors
Cell Biology
Cell cycle
Cell growth
Cell lines
Cell migration
Cell proliferation
Glioblastoma
Glioma cells
Neurobiology
Neurosciences
Original Research
Smad4 protein
Therapeutic targets
Transforming growth factor-b
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Zusammenfassung:Gliomas are aggressive brain tumors characterized by uncontrolled cell proliferation. FAM64A, a cell cycle-related gene, has been found to promote cell proliferation in various tumors, including gliomas. However, the regulatory mechanism and clinical significance of FAM64A in gliomas remain unclear. In this study, we investigated FAM64A expression in gliomas with different grades and constructed FAM64A silenced cell lines to study its functions. Our results demonstrated that FAM64A was highly expressed in glioblastoma ( P
ISSN:0272-4340
1573-6830
DOI:10.1007/s10571-023-01348-2