Synthesis of Disulfide Surrogate Peptides through a Serine/Threonine Ligation-Assisted Diaminodiacid Strategy

Synthesis of Disulfide Surrogate Peptides through a Serine/Threonine Ligation-Assisted Diaminodiacid Strategy

We report a new serine/threonine ligation (STL)-assisted diaminodiacid (DADA) strategy for the flexible construction of disulfide surrogates by the option of more abundant -Aa-Ser/Thr- ligation sites. The practicality of this strategy was evidenced by the synthesis of the intrachain disulfide surrog...

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Veröffentlicht in:Organic letters 2023-04, Vol.25 (16), p.2939-2943
Hauptverfasser: Tang, Jia-Hui, Yuan, Ru-Jing, Luo, Jie, Wang, Ning, Wang, Jun, Li, Yi-Ming
Format: Artikel
Sprache:eng
Schlagworte:
Disulfides
Peptides
Serine
Threonine
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Zusammenfassung:We report a new serine/threonine ligation (STL)-assisted diaminodiacid (DADA) strategy for the flexible construction of disulfide surrogates by the option of more abundant -Aa-Ser/Thr- ligation sites. The practicality of this strategy was evidenced by the synthesis of the intrachain disulfide surrogate of C-type natriuretic peptide and the interchain disulfide surrogate of insulin.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.3c01078