Clinical validation of methylation biomarkers for optimal detection of high‐grade vulvar intraepithelial neoplasia

The precursor lesions of vulvar squamous cell carcinoma (VSCC) include human papillomavirus (HPV)‐associated and HPV‐independent squamous neoplasia with a varying cancer risk. Our study aimed to validate the accuracy of previously identified DNA methylation markers for detection of such high‐grade v...

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Veröffentlicht in:	International journal of cancer 2023-08, Vol.153 (4), p.783-791
Hauptverfasser:	Voss, Féline O., Thuijs, Nikki B., Duin, Sylvia, Özer, Müjde, Beurden, Marc, Berkhof, Johannes, Steenbergen, Renske D. M., Bleeker, Maaike C. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Accuracy biomarker Biomarkers Cancer Clinical decision making Clinical outcomes Diagnostics DNA methylation Epigenetics Genital cancers Health risk assessment Health risks Human papillomavirus Lesions Medical research Predictions Squamous cell carcinoma Targeted cancer therapy vulvar intraepithelial neoplasia
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