Protective effects of pumpkin polysaccharide hydrolysates on oxidative stress injury and its potential mechanism — Antioxidant mechanism of pumpkin polysaccharide hydrolysates

Protective effects of pumpkin polysaccharide hydrolysates on oxidative stress injury and its potential mechanism — Antioxidant mechanism of pumpkin polysaccharide hydrolysates

Pumpkin polysaccharides (PPe) exhibit multiple bioactive properties, including the ability to reduce blood sugar and lipids. Our prior investigation discovered that hydrolysates (PPe-s) derived from PPe demonstrated stronger antioxidant capabilities than PPe. The objective of the current study was t...

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Veröffentlicht in:International journal of biological macromolecules 2023-06, Vol.241, p.124423-124423, Article 124423
Hauptverfasser: Gao, Xiaofeng, Yang, Zeen, Huang, Lingte, Zuo, Siying, Li, Xinghan, Li, Jia, Jiang, Wen, Wang, Shuang, Zhang, Yongjun
Format: Artikel
Sprache:eng
Schlagworte:
Acid-hydrolysis
Antioxidant-related genes
Pumpkin polysaccharides
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Zusammenfassung:Pumpkin polysaccharides (PPe) exhibit multiple bioactive properties, including the ability to reduce blood sugar and lipids. Our prior investigation discovered that hydrolysates (PPe-s) derived from PPe demonstrated stronger antioxidant capabilities than PPe. The objective of the current study was to explore the potential mechanism of PPe-s, utilizing Caenorhabditis elegans and MIN6 cells as models. The results of this investigation revealed that PPe-s exhibited strong scavenging ability towards ABTS+ and OH·in vitro. Additionally, PPe-s extended the lifespan of C. elegans under hydrogen peroxide stress (p 1.43-fold, p 
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2023.124423