Sodium citrate effectively used in shed mediastinal blood autotransfusion after cardiac surgery
Background We used sodium citrate as an alternative anticoagulation agent to heparin in the procedure of autologous blood transfusion with patients with postoperative haemorrhage after CPB. The aim of study was to evaluate the efficacy and safety of sodium citrate used in shed mediastinal blood auto...
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Veröffentlicht in: | Perfusion 2024-09, Vol.39 (6), p.1106-1112 |
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description | Background
We used sodium citrate as an alternative anticoagulation agent to heparin in the procedure of autologous blood transfusion with patients with postoperative haemorrhage after CPB. The aim of study was to evaluate the efficacy and safety of sodium citrate used in shed mediastinal blood autotransfusion after cardiac surgery.
Methods
Ninety-three patients were divided into two groups in this study. In the control group, 52 patients’ shed mediastinal blood was discarded. The reinfusion group consisted of 41 patients receiving a reinfusion of washed autologous red cells from shed mediastinal blood. Each 400 mL shed blood sample was anticoagulated by 140 mL of 1.6% diluted sodium citrate in the washing procedure using a blood recovery machine. Hemoglobin (Hb), hematocrit (Hct), and electrolyte concentrations in both the patients and shed mediastinal blood were measured before and after this procedure.
Results
The mean volume of autotransfused shed blood was 239.5 ± 54.6 mL.The Hct of the washed red cells was 56.8 ± 6.1%. Significantly, fewer units of allogeneic blood were required per patient in the reinfusion group at 24 h postoperatively (2.91 ± 1.34 vs 4.03 ± 0.19 U, p = 0.002). At 24 h postoperatively, Hb and Hct levels were higher in the reinfusion group than in the control group. The calcium ion concentration was very low in the shed mediastinal blood, 0.25 ± 0.08 mmol/L, and was lower after washing, 0.15 ± 0.04 mmol/L.
Conclusions
Sodium citrate, as an alternative anticoagulant agent, can be used in autologous shed mediastinal blood transfusion after CPB cardiac surgery. This procedure can effectively reduce the amount of allogeneic blood for patients with haemorrhage. |
doi_str_mv | 10.1177/02676591231171271 |
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fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2801982533</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_02676591231171271</sage_id><sourcerecordid>2801982533</sourcerecordid><originalsourceid>FETCH-LOGICAL-c320t-3345224dcd1fdf6a5bc152a8ba2c794d355cdc08054aed1ef131a22dc335c4c03</originalsourceid><addsrcrecordid>eNp1kMtKAzEUhoMotlYfwI0E3LiZmpPLTLuU4g0EFyq4GzK51JTppCYToW9vSquC4uoQzvf_h3wInQIZA1TVJaFlVYopUJafQCvYQ0PgVVUAwOs-Gm72xQYYoKMYF4QQzjk7RANWkZJQMR2i-slrl5ZYuT7I3mBjrVG9-zDtGqdoNHYdjm95Lo12Mvauky1uWu81lqn3OdRFm6LzHZa2NwErGTKocExhbsL6GB1Y2UZzspsj9HJz_Ty7Kx4eb-9nVw-FYpT0BWNcUMq10mC1LaVoFAgqJ42kqppyzYRQWpEJEVwaDcYCA0mpVowJxRVhI3Sx7V0F_55M7Ouli8q0reyMT7GmEwLTCRWMZfT8F7rwKeR_xTp7JBQ4KWmmYEup4GMMxtar4JYyrGsg9cZ-_cd-zpztmlOTfX0nvnRnYLwFopybn7P_N34CXVCNJQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3110214062</pqid></control><display><type>article</type><title>Sodium citrate effectively used in shed mediastinal blood autotransfusion after cardiac surgery</title><source>MEDLINE</source><source>SAGE Complete</source><creator>Hao, Xinghai ; Chen, Yueling ; Wang, Liangshan ; Jia, Ming ; Lu, Yang</creator><creatorcontrib>Hao, Xinghai ; Chen, Yueling ; Wang, Liangshan ; Jia, Ming ; Lu, Yang</creatorcontrib><description>Background
We used sodium citrate as an alternative anticoagulation agent to heparin in the procedure of autologous blood transfusion with patients with postoperative haemorrhage after CPB. The aim of study was to evaluate the efficacy and safety of sodium citrate used in shed mediastinal blood autotransfusion after cardiac surgery.
Methods
Ninety-three patients were divided into two groups in this study. In the control group, 52 patients’ shed mediastinal blood was discarded. The reinfusion group consisted of 41 patients receiving a reinfusion of washed autologous red cells from shed mediastinal blood. Each 400 mL shed blood sample was anticoagulated by 140 mL of 1.6% diluted sodium citrate in the washing procedure using a blood recovery machine. Hemoglobin (Hb), hematocrit (Hct), and electrolyte concentrations in both the patients and shed mediastinal blood were measured before and after this procedure.
Results
The mean volume of autotransfused shed blood was 239.5 ± 54.6 mL.The Hct of the washed red cells was 56.8 ± 6.1%. Significantly, fewer units of allogeneic blood were required per patient in the reinfusion group at 24 h postoperatively (2.91 ± 1.34 vs 4.03 ± 0.19 U, p = 0.002). At 24 h postoperatively, Hb and Hct levels were higher in the reinfusion group than in the control group. The calcium ion concentration was very low in the shed mediastinal blood, 0.25 ± 0.08 mmol/L, and was lower after washing, 0.15 ± 0.04 mmol/L.
Conclusions
Sodium citrate, as an alternative anticoagulant agent, can be used in autologous shed mediastinal blood transfusion after CPB cardiac surgery. This procedure can effectively reduce the amount of allogeneic blood for patients with haemorrhage.</description><identifier>ISSN: 0267-6591</identifier><identifier>ISSN: 1477-111X</identifier><identifier>EISSN: 1477-111X</identifier><identifier>DOI: 10.1177/02676591231171271</identifier><identifier>PMID: 37060259</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Aged ; Anticoagulants ; Anticoagulants - therapeutic use ; Autotransfusion ; Blood levels ; Blood transfusion ; Blood Transfusion, Autologous - methods ; Blood transfusions ; Calcium (blood) ; Calcium ions ; Cardiac Surgical Procedures - methods ; Citrates - pharmacology ; Citric acid ; Electrolytic cells ; Female ; Heart ; Heart surgery ; Hematocrit ; Hemoglobin ; Hemorrhage ; Heparin ; Humans ; Ion concentration ; Male ; Middle Aged ; Operative Blood Salvage - methods ; Postoperative Hemorrhage - blood ; Postoperative Hemorrhage - prevention & control ; Postoperative Hemorrhage - therapy ; Sodium ; Sodium citrate ; Sodium Citrate - pharmacology ; Surgery ; Transfusion ; Washing</subject><ispartof>Perfusion, 2024-09, Vol.39 (6), p.1106-1112</ispartof><rights>The Author(s) 2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c320t-3345224dcd1fdf6a5bc152a8ba2c794d355cdc08054aed1ef131a22dc335c4c03</cites><orcidid>0000-0002-3135-5125</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/02676591231171271$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/02676591231171271$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37060259$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hao, Xinghai</creatorcontrib><creatorcontrib>Chen, Yueling</creatorcontrib><creatorcontrib>Wang, Liangshan</creatorcontrib><creatorcontrib>Jia, Ming</creatorcontrib><creatorcontrib>Lu, Yang</creatorcontrib><title>Sodium citrate effectively used in shed mediastinal blood autotransfusion after cardiac surgery</title><title>Perfusion</title><addtitle>Perfusion</addtitle><description>Background
We used sodium citrate as an alternative anticoagulation agent to heparin in the procedure of autologous blood transfusion with patients with postoperative haemorrhage after CPB. The aim of study was to evaluate the efficacy and safety of sodium citrate used in shed mediastinal blood autotransfusion after cardiac surgery.
Methods
Ninety-three patients were divided into two groups in this study. In the control group, 52 patients’ shed mediastinal blood was discarded. The reinfusion group consisted of 41 patients receiving a reinfusion of washed autologous red cells from shed mediastinal blood. Each 400 mL shed blood sample was anticoagulated by 140 mL of 1.6% diluted sodium citrate in the washing procedure using a blood recovery machine. Hemoglobin (Hb), hematocrit (Hct), and electrolyte concentrations in both the patients and shed mediastinal blood were measured before and after this procedure.
Results
The mean volume of autotransfused shed blood was 239.5 ± 54.6 mL.The Hct of the washed red cells was 56.8 ± 6.1%. Significantly, fewer units of allogeneic blood were required per patient in the reinfusion group at 24 h postoperatively (2.91 ± 1.34 vs 4.03 ± 0.19 U, p = 0.002). At 24 h postoperatively, Hb and Hct levels were higher in the reinfusion group than in the control group. The calcium ion concentration was very low in the shed mediastinal blood, 0.25 ± 0.08 mmol/L, and was lower after washing, 0.15 ± 0.04 mmol/L.
Conclusions
Sodium citrate, as an alternative anticoagulant agent, can be used in autologous shed mediastinal blood transfusion after CPB cardiac surgery. This procedure can effectively reduce the amount of allogeneic blood for patients with haemorrhage.</description><subject>Aged</subject><subject>Anticoagulants</subject><subject>Anticoagulants - therapeutic use</subject><subject>Autotransfusion</subject><subject>Blood levels</subject><subject>Blood transfusion</subject><subject>Blood Transfusion, Autologous - methods</subject><subject>Blood transfusions</subject><subject>Calcium (blood)</subject><subject>Calcium ions</subject><subject>Cardiac Surgical Procedures - methods</subject><subject>Citrates - pharmacology</subject><subject>Citric acid</subject><subject>Electrolytic cells</subject><subject>Female</subject><subject>Heart</subject><subject>Heart surgery</subject><subject>Hematocrit</subject><subject>Hemoglobin</subject><subject>Hemorrhage</subject><subject>Heparin</subject><subject>Humans</subject><subject>Ion concentration</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Operative Blood Salvage - methods</subject><subject>Postoperative Hemorrhage - blood</subject><subject>Postoperative Hemorrhage - prevention & control</subject><subject>Postoperative Hemorrhage - therapy</subject><subject>Sodium</subject><subject>Sodium citrate</subject><subject>Sodium Citrate - pharmacology</subject><subject>Surgery</subject><subject>Transfusion</subject><subject>Washing</subject><issn>0267-6591</issn><issn>1477-111X</issn><issn>1477-111X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtKAzEUhoMotlYfwI0E3LiZmpPLTLuU4g0EFyq4GzK51JTppCYToW9vSquC4uoQzvf_h3wInQIZA1TVJaFlVYopUJafQCvYQ0PgVVUAwOs-Gm72xQYYoKMYF4QQzjk7RANWkZJQMR2i-slrl5ZYuT7I3mBjrVG9-zDtGqdoNHYdjm95Lo12Mvauky1uWu81lqn3OdRFm6LzHZa2NwErGTKocExhbsL6GB1Y2UZzspsj9HJz_Ty7Kx4eb-9nVw-FYpT0BWNcUMq10mC1LaVoFAgqJ42kqppyzYRQWpEJEVwaDcYCA0mpVowJxRVhI3Sx7V0F_55M7Ouli8q0reyMT7GmEwLTCRWMZfT8F7rwKeR_xTp7JBQ4KWmmYEup4GMMxtar4JYyrGsg9cZ-_cd-zpztmlOTfX0nvnRnYLwFopybn7P_N34CXVCNJQ</recordid><startdate>20240901</startdate><enddate>20240901</enddate><creator>Hao, Xinghai</creator><creator>Chen, Yueling</creator><creator>Wang, Liangshan</creator><creator>Jia, Ming</creator><creator>Lu, Yang</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3135-5125</orcidid></search><sort><creationdate>20240901</creationdate><title>Sodium citrate effectively used in shed mediastinal blood autotransfusion after cardiac surgery</title><author>Hao, Xinghai ; Chen, Yueling ; Wang, Liangshan ; Jia, Ming ; Lu, Yang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c320t-3345224dcd1fdf6a5bc152a8ba2c794d355cdc08054aed1ef131a22dc335c4c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Anticoagulants</topic><topic>Anticoagulants - therapeutic use</topic><topic>Autotransfusion</topic><topic>Blood levels</topic><topic>Blood transfusion</topic><topic>Blood Transfusion, Autologous - methods</topic><topic>Blood transfusions</topic><topic>Calcium (blood)</topic><topic>Calcium ions</topic><topic>Cardiac Surgical Procedures - methods</topic><topic>Citrates - pharmacology</topic><topic>Citric acid</topic><topic>Electrolytic cells</topic><topic>Female</topic><topic>Heart</topic><topic>Heart surgery</topic><topic>Hematocrit</topic><topic>Hemoglobin</topic><topic>Hemorrhage</topic><topic>Heparin</topic><topic>Humans</topic><topic>Ion concentration</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Operative Blood Salvage - methods</topic><topic>Postoperative Hemorrhage - blood</topic><topic>Postoperative Hemorrhage - prevention & control</topic><topic>Postoperative Hemorrhage - therapy</topic><topic>Sodium</topic><topic>Sodium citrate</topic><topic>Sodium Citrate - pharmacology</topic><topic>Surgery</topic><topic>Transfusion</topic><topic>Washing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hao, Xinghai</creatorcontrib><creatorcontrib>Chen, Yueling</creatorcontrib><creatorcontrib>Wang, Liangshan</creatorcontrib><creatorcontrib>Jia, Ming</creatorcontrib><creatorcontrib>Lu, Yang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Perfusion</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hao, Xinghai</au><au>Chen, Yueling</au><au>Wang, Liangshan</au><au>Jia, Ming</au><au>Lu, Yang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sodium citrate effectively used in shed mediastinal blood autotransfusion after cardiac surgery</atitle><jtitle>Perfusion</jtitle><addtitle>Perfusion</addtitle><date>2024-09-01</date><risdate>2024</risdate><volume>39</volume><issue>6</issue><spage>1106</spage><epage>1112</epage><pages>1106-1112</pages><issn>0267-6591</issn><issn>1477-111X</issn><eissn>1477-111X</eissn><abstract>Background
We used sodium citrate as an alternative anticoagulation agent to heparin in the procedure of autologous blood transfusion with patients with postoperative haemorrhage after CPB. The aim of study was to evaluate the efficacy and safety of sodium citrate used in shed mediastinal blood autotransfusion after cardiac surgery.
Methods
Ninety-three patients were divided into two groups in this study. In the control group, 52 patients’ shed mediastinal blood was discarded. The reinfusion group consisted of 41 patients receiving a reinfusion of washed autologous red cells from shed mediastinal blood. Each 400 mL shed blood sample was anticoagulated by 140 mL of 1.6% diluted sodium citrate in the washing procedure using a blood recovery machine. Hemoglobin (Hb), hematocrit (Hct), and electrolyte concentrations in both the patients and shed mediastinal blood were measured before and after this procedure.
Results
The mean volume of autotransfused shed blood was 239.5 ± 54.6 mL.The Hct of the washed red cells was 56.8 ± 6.1%. Significantly, fewer units of allogeneic blood were required per patient in the reinfusion group at 24 h postoperatively (2.91 ± 1.34 vs 4.03 ± 0.19 U, p = 0.002). At 24 h postoperatively, Hb and Hct levels were higher in the reinfusion group than in the control group. The calcium ion concentration was very low in the shed mediastinal blood, 0.25 ± 0.08 mmol/L, and was lower after washing, 0.15 ± 0.04 mmol/L.
Conclusions
Sodium citrate, as an alternative anticoagulant agent, can be used in autologous shed mediastinal blood transfusion after CPB cardiac surgery. This procedure can effectively reduce the amount of allogeneic blood for patients with haemorrhage.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>37060259</pmid><doi>10.1177/02676591231171271</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-3135-5125</orcidid></addata></record> |
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subjects | Aged Anticoagulants Anticoagulants - therapeutic use Autotransfusion Blood levels Blood transfusion Blood Transfusion, Autologous - methods Blood transfusions Calcium (blood) Calcium ions Cardiac Surgical Procedures - methods Citrates - pharmacology Citric acid Electrolytic cells Female Heart Heart surgery Hematocrit Hemoglobin Hemorrhage Heparin Humans Ion concentration Male Middle Aged Operative Blood Salvage - methods Postoperative Hemorrhage - blood Postoperative Hemorrhage - prevention & control Postoperative Hemorrhage - therapy Sodium Sodium citrate Sodium Citrate - pharmacology Surgery Transfusion Washing |
title | Sodium citrate effectively used in shed mediastinal blood autotransfusion after cardiac surgery |
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