Cell signaling pathways based on vitamin C and their application in cancer therapy

Vitamin C, a small organic molecule, is widely found in fruits and vegetables and is an essential nutrient in the human body. Vitamin C is closely associated with some human diseases such as cancer. Many studies have shown that high doses of vitamin C have anti-tumor ability and can target tumor cel...

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Veröffentlicht in:Biomedicine & pharmacotherapy 2023-06, Vol.162, p.114695-114695, Article 114695
Hauptverfasser: Fan, Dianfa, Liu, Xiyu, Shen, Zhen, Wu, Pan, Zhong, Liping, Lin, Faquan
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Sprache:eng
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Zusammenfassung:Vitamin C, a small organic molecule, is widely found in fruits and vegetables and is an essential nutrient in the human body. Vitamin C is closely associated with some human diseases such as cancer. Many studies have shown that high doses of vitamin C have anti-tumor ability and can target tumor cells in multiple targets. This review will describe vitamin C absorption and its function in cancer treatment. We will review the cellular signaling pathways associated with vitamin C against tumors depending on the different anti-cancer mechanisms. Based on this, we will further describe some applications of the use of vitamin C for cancer treatment in preclinical and clinical trials and the possible adverse events that can occur. Finally, this review also assesses the prospective advantages of vitamin C in oncology treatment and clinical applications.
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2023.114695