Lifting the curtain on molecular differences between malignant pleural mesotheliomas

We introduce molecular and cellular criteria — based on morphology, ploidy, CpG island methylation and immune infiltration — that improve the characterization of malignant pleural mesothelioma. These criteria reveal adaptation strategies that are adopted by tumor cells and offer new possibilities fo...

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Veröffentlicht in:	Nature genetics 2023-04, Vol.55 (4), p.540-541
Hauptverfasser:	Alcala, Nicolas, Fernandez-Cuesta, Lynnette
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/212 631/67/1641 Agriculture Animal Genetics and Genomics Asbestos Bioinformatics Biomedical and Life Sciences Biomedicine Cancer Cancer Research Cell division Classification Cooperation CpG islands DNA methylation Gene expression Gene Function Gene regulation Genomes Genomics Human Genetics Humans Lifting Lung Neoplasms - genetics Mesothelioma Mesothelioma - genetics Mesothelioma - pathology Mesothelioma, Malignant Methylation Morphology Pleura Pleural Neoplasms - genetics Pleural Neoplasms - pathology Research Briefing Tumors
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Beschreibung
Zusammenfassung:	We introduce molecular and cellular criteria — based on morphology, ploidy, CpG island methylation and immune infiltration — that improve the characterization of malignant pleural mesothelioma. These criteria reveal adaptation strategies that are adopted by tumor cells and offer new possibilities for classification and clinical management.
ISSN:	1061-4036 1546-1718
DOI:	10.1038/s41588-023-01322-0