Variation in Treatment of Pediatric Tuberculosis Infection in Different Provider Settings

To evaluate implementation of rifamycin-based regimens (RBR) for pediatric tuberculosis infection (TBI) treatment among 3 provider settings in a high-incidence county. A multicenter, retrospective observational study was performed across 3 sites in Los Angeles County: an academic center (AC), a gene...

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Veröffentlicht in:The Journal of pediatrics 2023-08, Vol.259, p.113419-113419, Article 113419
Hauptverfasser: Malhotra, Sanchi, Dasgupta-Tsinikas, Shom, Yumul, Josephine, Kaneta, Kelli, Lenz, Annika, Kizzee, Richard, Bihm, Dustin, Jung, Christina, Neely, Michael, Guevara, Ramon E., Higashi, Julie, Bender, Jeffrey M.
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container_title The Journal of pediatrics
container_volume 259
creator Malhotra, Sanchi
Dasgupta-Tsinikas, Shom
Yumul, Josephine
Kaneta, Kelli
Lenz, Annika
Kizzee, Richard
Bihm, Dustin
Jung, Christina
Neely, Michael
Guevara, Ramon E.
Higashi, Julie
Bender, Jeffrey M.
description To evaluate implementation of rifamycin-based regimens (RBR) for pediatric tuberculosis infection (TBI) treatment among 3 provider settings in a high-incidence county. A multicenter, retrospective observational study was performed across 3 sites in Los Angeles County: an academic center (AC), a general pediatrics federally qualified health center (FQHC), and department of public health (DPH) tuberculosis clinics. Patients initiated on TBI treatment age 1 months to 17 years between 2018 and 2020 were included. RBRs were defined as regimens: 3 months of weekly rifapentine and isoniazid, 4 months of daily rifampin, and 3 months of daily isoniazid and rifampin. We included 424 patients: 51 from AC, 327 from DPH, and 46 from FQHC. RBR use nearly doubled during the study period (from 43% in 2018 to 82% in 2020; P 
doi_str_mv 10.1016/j.jpeds.2023.113419
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A multicenter, retrospective observational study was performed across 3 sites in Los Angeles County: an academic center (AC), a general pediatrics federally qualified health center (FQHC), and department of public health (DPH) tuberculosis clinics. Patients initiated on TBI treatment age 1 months to 17 years between 2018 and 2020 were included. RBRs were defined as regimens: 3 months of weekly rifapentine and isoniazid, 4 months of daily rifampin, and 3 months of daily isoniazid and rifampin. We included 424 patients: 51 from AC, 327 from DPH, and 46 from FQHC. RBR use nearly doubled during the study period (from 43% in 2018 to 82% in 2020; P &lt; .001). FQHC had the shortest time to chest radiograph and treatment initiation; however, AC and DPH were 4 times as likely to prescribe an RBR compared to FQHC (95% CI, 2.1-7.8). AC and DPH had similar completion rates (74%) and were 2.6 times as likely to complete treatment compared to FQHC (95% CI, 1.4-4.9). 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subjects infectious diseases
public health
tuberculosis elimination
title Variation in Treatment of Pediatric Tuberculosis Infection in Different Provider Settings
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