A Type I/Type III PKS Hybrid Generates Cinnamomycin A–D

A Type I/Type III PKS Hybrid Generates Cinnamomycin A–D

3,5-Dihydroxybenzoic acid (3,5-DHBA), biosynthesized by type III PKS and tailoring enzymes, is an unconventional starter unit for bacterial type I PKS. Genome mining of 3,5-DHBA-specific biosynthetic gene clusters could lead to discovering new type I/type III PKS hybrids. Herein, we report the disco...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic letters 2023-04, Vol.25 (15), p.2560-2564
Hauptverfasser: Zhang, Bei, Jin, Wenzheng, Zhang, Yunyun, Dai, Yan, Li, Haohao, Sun, Yanzi, Wu, Xuri, Luo, Jun, Chen, Yijun
Format: Artikel
Sprache:eng
Schlagworte:
Bacteria - metabolism
Multigene Family
Polyketide Synthases - metabolism
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:3,5-Dihydroxybenzoic acid (3,5-DHBA), biosynthesized by type III PKS and tailoring enzymes, is an unconventional starter unit for bacterial type I PKS. Genome mining of 3,5-DHBA-specific biosynthetic gene clusters could lead to discovering new type I/type III PKS hybrids. Herein, we report the discovery and characterization of atypical compounds, namely cinnamomycin A–D, exhibiting selective antiproliferative activity. The biosynthetic pathway of cinnamomycins was proposed based on genetic manipulation, enzymatic reaction, and precursor feeding.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.3c00293