Mean Arterial Pressure and Cerebral Hemodynamics Across The Lifespan: A Cross‐Sectional Study From Human Connectome Project‐Aging

Background Cerebral perfusion is directly affected by systemic blood pressure, which has been shown to be negatively correlated with cerebral blood flow (CBF). The impact of aging on these effects is not fully understood. Purpose To determine whether the relationship between mean arterial pressure (MAP) and cerebral hemodynamics persists throughout the lifespan. Study Type Retrospective, cross‐sectional study. Population Six hundred and sixty‐nine participants from the Human Connectome Project‐Aging ranging between 36 and 100+ years and without a major neurological disorder. Field Strength/Sequence Imaging data was acquired at 3.0 Tesla using a 32‐channel head coil. CBF and arterial transit time (ATT) were measured by multi‐delay pseudo‐continuous arterial spin labeling. Assessment The relationships between cerebral hemodynamic parameters and MAP were evaluated globally in gray and white matter and regionally using surface‐based analysis in the whole group, separately within different age groups (young: