Replication licensing during S phase: breaking the law to prevent breaking DNA
A cardinal rule of DNA replication is to prevent any possibility of pre-replication complexes re-loading during S phase, risking genotoxic over-replication. But can this rule be broken in emergency situations to preserve genome integrity?
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| Veröffentlicht in: | Nature structural & molecular biology 2023-04, Vol.30 (4), p.406-408 |
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| container_title | Nature structural & molecular biology |
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| creator | Gilbert, David M. |
| description | A cardinal rule of DNA replication is to prevent any possibility of pre-replication complexes re-loading during S phase, risking genotoxic over-replication. But can this rule be broken in emergency situations to preserve genome integrity? |
| doi_str_mv | 10.1038/s41594-023-00962-4 |
| format | Article |
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| subjects | 13 13/106 631/208/211 631/337/151 631/337/151/2355 631/337/151/2357 631/80/641/2187 Biochemistry Biological Microscopy Biomedical and Life Sciences Cell Cycle Cell Cycle Proteins - metabolism Deoxyribonucleic acid DNA DNA biosynthesis DNA damage DNA Replication Genes Genomes Genotoxicity Hypotheses Life Sciences Membrane Biology Molecular biology News & Views news-and-views Protein Structure Replication Replication Origin S Phase |
| title | Replication licensing during S phase: breaking the law to prevent breaking DNA |
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