Replication licensing during S phase: breaking the law to prevent breaking DNA

Replication licensing during S phase: breaking the law to prevent breaking DNA

A cardinal rule of DNA replication is to prevent any possibility of pre-replication complexes re-loading during S phase, risking genotoxic over-replication. But can this rule be broken in emergency situations to preserve genome integrity?

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Bibliographische Detailangaben
Veröffentlicht in:Nature structural & molecular biology 2023-04, Vol.30 (4), p.406-408
1. Verfasser: Gilbert, David M.
Format: Artikel
Sprache:eng
Schlagworte:
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Biochemistry
Biological Microscopy
Biomedical and Life Sciences
Cell Cycle
Cell Cycle Proteins - metabolism
Deoxyribonucleic acid
DNA
DNA biosynthesis
DNA damage
DNA Replication
Genes
Genomes
Genotoxicity
Hypotheses
Life Sciences
Membrane Biology
Molecular biology
News & Views
news-and-views
Protein Structure
Replication
Replication Origin
S Phase
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Beschreibung
Zusammenfassung:A cardinal rule of DNA replication is to prevent any possibility of pre-replication complexes re-loading during S phase, risking genotoxic over-replication. But can this rule be broken in emergency situations to preserve genome integrity?
ISSN:1545-9993
1545-9985
DOI:10.1038/s41594-023-00962-4