Mutations in IFN-γ signaling genes sensitize tumors to immune checkpoint blockade

Mutations in IFN-γ signaling genes sensitize tumors to immune checkpoint blockade

Song and Chow demonstrate that while tumor-intrinsic mutations in the IFN-γ signaling pathway confer immune resistance across in vitro co-culture systems, such alterations associate with enhanced anti-tumor immunity in vivo and improved responsiveness to immune checkpoint blockade therapy in patient...

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Veröffentlicht in:Cancer cell 2023-04, Vol.41 (4), p.651-652
Hauptverfasser: Song, Eric, Chow, Ryan D.
Format: Artikel
Sprache:eng
Schlagworte:
Humans
Immune Checkpoint Inhibitors - pharmacology
Immune Checkpoint Inhibitors - therapeutic use
Mutation
Neoplasms - drug therapy
Neoplasms - genetics
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Zusammenfassung:Song and Chow demonstrate that while tumor-intrinsic mutations in the IFN-γ signaling pathway confer immune resistance across in vitro co-culture systems, such alterations associate with enhanced anti-tumor immunity in vivo and improved responsiveness to immune checkpoint blockade therapy in patients with cancer.
ISSN:1535-6108
1878-3686
1878-3686
DOI:10.1016/j.ccell.2023.02.013