Large-Scale Virtual Screening for the Discovery of SARS-CoV‑2 Papain-like Protease (PLpro) Non-covalent Inhibitors

The rapid global spread of the SARS-CoV-2 virus facilitated the development of novel direct-acting antiviral agents (DAAs). The papain-like protease (PLpro) has been proposed as one of the major SARS-CoV-2 targets for DAAs due to its dual role in processing viral proteins and facilitating the host’s...

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Veröffentlicht in:	Journal of chemical information and modeling 2023-04, Vol.63 (7), p.2158-2169
Hauptverfasser:	Garland, Olivia, Ton, Anh-Tien, Moradi, Shoeib, Smith, Jason R., Kovacic, Suzana, Ng, Kurtis, Pandey, Mohit, Ban, Fuqiang, Lee, Jaeyong, Vuckovic, Marija, Worrall, Liam J., Young, Robert N., Pantophlet, Ralph, Strynadka, Natalie C. J., Cherkasov, Artem
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - chemistry Antiviral Agents - pharmacology Computational Biochemistry COVID-19 Docking Hepatitis C, Chronic Humans Models, Molecular Papain Peptide Hydrolases Prospective Studies Protease Protease inhibitors Protease Inhibitors - chemistry Protease Inhibitors - pharmacology Proteins SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Viral diseases Viral Proteins - chemistry
Online-Zugang:	Volltext
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