Mini-review: Interaction between intestinal microbes and enteric glia in health and disease

•Emerging evidence supports a species- and subtype-specific communication between enteric glia and intestinal microbiota.•Enteric glia discriminate between luminal pathogens and probiotics.•Enteroglial-derived S100B protein positively correlates with microbiota biodiversity and mediates the glial response to intestinal pathogens. Enteric glia are a unique population of peripheral neuroglia associated with the enteric nervous system (ENS) throughout the digestive tract. The emerging data from the latest glial biology studies unveiled enteric glia as a heterogenic population with plastic and adaptative abilities that display phenotypic and functional changes upon distinct extrinsic cues. This aspect is essential in the dynamic signaling that enteric glia engage with neurons and other neighboring cells within the intestinal wall, such as epithelial, endocrine, and immune cells to maintain local homeostasis. Likewise, enteric glia sense signals from luminal microbes, although the extent of this active communication is still unclear. In this minireview, we discuss the recent findings that support glia-microbes crosstalk in the intestine in health and disease, pointing out the critical aspects that require further investigation.