Dissolution Profiles of Poorly Soluble Drug Salts in Bicarbonate Buffer

Dissolution Profiles of Poorly Soluble Drug Salts in Bicarbonate Buffer

Purpose The purpose of the present study was to investigate the effect of buffer species on the dissolution profiles of poorly soluble drug salts, focusing on bicarbonate buffer (BCB). Methods Pioglitazone HCl (PIO HCl) and dantrolene sodium (DNT Na) were used as model drugs. Non-sink dissolution te...

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Veröffentlicht in:Pharmaceutical research 2023-04, Vol.40 (4), p.989-998
Hauptverfasser: Sakamoto, Aoi, Sugano, Kiyohiko
Format: Artikel
Sprache:eng
Schlagworte:
Analysis
Bicarbonates
Bile
Biochemistry
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Biomedicine
Carbon dioxide
Carbonates
Dantrolene
Dissolution
Drugs
Hydrogen-Ion Concentration
Ionic strength
Light microscopy
Medical Law
Micelles
Microscopy
Original Research Article
pH effects
Pharmacology/Toxicology
Pharmacy
Phosphates
Pioglitazone
Polarized light
Powders
Salts
Scanning electron microscopy
Sodium Chloride
Solubility
X-ray diffraction
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Zusammenfassung:Purpose The purpose of the present study was to investigate the effect of buffer species on the dissolution profiles of poorly soluble drug salts, focusing on bicarbonate buffer (BCB). Methods Pioglitazone HCl (PIO HCl) and dantrolene sodium (DNT Na) were used as model drugs. Non-sink dissolution tests were performed using phosphate buffer (PB) and BCB (pH 6.5, buffer capacity: 4.4 mM/pH, ionic strength: 0.14 M, with/ without bile micelles). The pH value of BCB was maintained using a floating lid that avoided the loss of CO 2 . The particles collected at the early stage of dissolution (
ISSN:0724-8741
1573-904X
DOI:10.1007/s11095-023-03508-x