Bivalent Prefusion F Vaccine in Pregnancy to Prevent RSV Illness in Infants

Maternal vaccination was 82% effective in preventing medically attended RSV-associated lower respiratory tract illness in infants within 90 days after birth and 69% effective within 180 days.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2023-04, Vol.388 (16), p.1451-1464
Hauptverfasser:	Kampmann, Beate, Madhi, Shabir A., Munjal, Iona, Simões, Eric A.F., Pahud, Barbara A., Llapur, Conrado, Baker, Jeffrey, Pérez Marc, Gonzalo, Radley, David, Shittu, Emma, Glanternik, Julia, Snaggs, Hasra, Baber, James, Zachariah, Philip, Barnabas, Shaun L., Fausett, Merlin, Adam, Tyler, Perreras, Nicole, Van Houten, Marlies A., Kantele, Anu, Huang, Li-Min, Bont, Louis J., Otsuki, Takeo, Vargas, Sergio L., Gullam, Joanna, Tapiero, Bruce, Stein, Renato T., Polack, Fernando P., Zar, Heather J., Staerke, Nina B., Duron Padilla, María, Richmond, Peter C., Koury, Kenneth, Schneider, Katherine, Kalinina, Elena V., Cooper, David, Jansen, Kathrin U., Anderson, Annaliesa S., Swanson, Kena A., Gruber, William C., Gurtman, Alejandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Antibodies Antibodies, Viral Antigens Babies Birth Birth weight Childhood Diseases Communicable Diseases - therapy Coronaviruses COVID-19 Double-Blind Method F protein Female Global Health Gynecology Gynecology General Humans Illnesses Immunization Infant Infant, Newborn Infants Infectious Disease Infectious Disease General Influenza Informed consent Injections, Intramuscular Neonates Neonatology Obstetrics Pediatrics Pediatrics General Placebos Pregnancy Premature birth Respiratory syncytial virus Respiratory Syncytial Virus Infections - epidemiology Respiratory Syncytial Virus Infections - prevention & control Respiratory Syncytial Virus Vaccines - administration & dosage Respiratory Syncytial Virus Vaccines - adverse effects Respiratory Syncytial Virus Vaccines - therapeutic use Respiratory Syncytial Viruses Respiratory tract Respiratory Tract Infections - epidemiology Respiratory Tract Infections - prevention & control Severe acute respiratory syndrome coronavirus 2 Treatment Outcome Vaccination - adverse effects Vaccination - methods Vaccine Efficacy Vaccines Vaccines, Combined - administration & dosage Vaccines, Combined - adverse effects Vaccines, Combined - therapeutic use Viral Infections Womens health
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Beschreibung
Zusammenfassung:	Maternal vaccination was 82% effective in preventing medically attended RSV-associated lower respiratory tract illness in infants within 90 days after birth and 69% effective within 180 days.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2216480