CAR T Cells for Neuroblastoma

This editorial explains the science behind a study of chimeric antigen receptor–expressing T cells to treat a series of 27 patients with neuroblastoma.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2023-04, Vol.388 (14), p.1328-1331
Hauptverfasser:	Yeku, Oladapo O., Longo, Dan L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antigens Apoptosis Blood cancer Cancer Cell Line, Tumor Chemotherapy Childhood Cancer Childhood Diseases Chimeric antigen receptors Cytokines Design Enzymes Genetics Genetics General Hematology Humans Hypotension Hypoxia Immunotherapy Immunotherapy, Adoptive - methods Lymphocytes Lymphocytes T Neuroblastoma Neuroblastoma - immunology Neuroblastoma - therapy Neurology Neurosurgery Neurosurgery General Oncology Patients Pediatrics Pediatrics General Receptors, Antigen, T-Cell Receptors, Chimeric Antigen - immunology Receptors, Chimeric Antigen - therapeutic use T-Lymphocytes - immunology Treatments in Oncology Tumor necrosis factor-TNF Tumors
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Beschreibung
Zusammenfassung:	This editorial explains the science behind a study of chimeric antigen receptor–expressing T cells to treat a series of 27 patients with neuroblastoma.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMe2300317