A Comparative Study of 18F-FAPI-42 and 18F-FDG PET/CT for Evaluating Acute Kidney Injury in Cancer Patients

Purpose Compare the value of imaging using positron 18 F-labeled fibroblast activation protein inhibitor-42 ( 18 F-FAPI-42) and 18 F-labeled deoxyglucose ( 18 F-FDG) for assessment of AKI. Procedures This study analyzed cancer patients who received 18 F-FAPI-42 and 18 F-FDG PET/CT imaging. Eight patients had AKI with bilateral ureteral obstruction (BUO), eight had BUO (CKD1–2) with no acute kidney disease (AKD), and eight had no ureteral obstruction (UO) with normal renal function. The average standardized uptake value (SUV ave ) of the renal parenchyma (RP-SUV ave ), the blood pool SUV ave (B- SUV ave ), SUV ave in the highest region of the renal collective system (RCS-SUV ave ), and the highest serum creatinine level (top SCr) were recorded. Results The 18 F-FAPI-42 and 18 F-FDG results showed that radiotracer of renal parenchyma was more concentrated in the AKI group than in the other two groups, whereas the RP-SUV ave from 18 F-FAPI-42 was higher than that from 18 F-FDG in the AKI group (all P