Functional Role of an Unusual Transmembrane Acidic Residue in the Calcium Pump Regulator Myoregulin

Myoregulin (MLN) is a member of the regulin family, a group of homologous membrane proteins that bind to and regulate the activity of the sarcoplasmic reticulum Ca2+-ATPase (SERCA). MLN, which is expressed in skeletal muscle, contains an acidic residue in its transmembrane domain. The location of th...

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Veröffentlicht in:	Biochemistry (Easton) 2023-04, Vol.62 (8), p.1331-1336
Hauptverfasser:	Liu, Andy Y., Rathod, Nishadh, Guerrero-Serna, Guadalupe, Young, Howard S., Espinoza-Fonseca, L. Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium - metabolism Calcium-Binding Proteins - chemistry Humans Ion Transport Molecular Conformation Muscle, Skeletal - metabolism Sarcoplasmic Reticulum - chemistry Sarcoplasmic Reticulum - metabolism Sarcoplasmic Reticulum Calcium-Transporting ATPases - chemistry Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism
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Beschreibung
Zusammenfassung:	Myoregulin (MLN) is a member of the regulin family, a group of homologous membrane proteins that bind to and regulate the activity of the sarcoplasmic reticulum Ca2+-ATPase (SERCA). MLN, which is expressed in skeletal muscle, contains an acidic residue in its transmembrane domain. The location of this residue, Asp35, is unusual because the relative occurrence of aspartate is very rare (
ISSN:	0006-2960 1520-4995
DOI:	10.1021/acs.biochem.3c00026