Photocatalytic synthesis of azaheterocycle-fused piperidines and pyrrolidines via tandem difunctionalization of unactivated alkenes

A variety of azaheterocycle-fused piperidines and pyrrolidines bearing CF and CHF functionalities were obtained using CF SO Na and CHF SO Na by visible light photocatalysis. This protocol involves a radical cascade cyclization tandem tri- and difluoromethylation-arylation of pendent unactivated alkenes. Benzimidazole, imidazole, theophylline, purine, and indole serve as applicable anchors, thereby enriching the structural diversity of piperidine and pyrrolidine derivatives. This method features mild, additive-free and transition metal-free conditions.