iGlarLixi provides a higher derived time‐in‐range versus insulin glargine 100 U/mL or lixisenatide in Asian Pacific people with type 2 diabetes: A post hoc analysis

Aim To evaluate the efficacy of iGlarLixi in the Asian Pacific (AP) population with type 2 diabetes (T2D) using derived time‐in‐ranges calculated from seven‐point self‐measured blood glucose. Methods Two phase III trials were analysed. LixiLan‐O‐AP was performed in insulin‐naive T2D patients (n = 87...

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Veröffentlicht in:Diabetes, obesity & metabolism obesity & metabolism, 2023-07, Vol.25 (7), p.2005-2011
Hauptverfasser: Guo, Xiaohui, Yang, Wenying, Zhang, Junqing, Dong, Xiaolin, Liu, Ming, Gu, Shenghong, Lauand, Felipe, Li, Lingyu, Huang, Qiong, Kang, Lei, Souhami, Elisabeth
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Sprache:eng
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Zusammenfassung:Aim To evaluate the efficacy of iGlarLixi in the Asian Pacific (AP) population with type 2 diabetes (T2D) using derived time‐in‐ranges calculated from seven‐point self‐measured blood glucose. Methods Two phase III trials were analysed. LixiLan‐O‐AP was performed in insulin‐naive T2D patients (n = 878) randomized to iGlarLixi, glargine 100 units/mL (iGlar) or lixisenatide (Lixi). LixiLan‐L‐CN was performed in insulin‐treated T2D patients (n = 426) randomized to iGlarLixi or iGlar. Changes in derived time‐in‐ranges from baseline to end‐of‐treatment (EOT) and estimated treatment differences (ETDs) were analysed. The proportions of patients achieving 70% or higher derived time‐in‐range (dTIR), 5% or higher dTIR improvement, and the composite triple target (≥ 70% dTIR,
ISSN:1462-8902
1463-1326
DOI:10.1111/dom.15074