Protocol letter: Intra-treatment Image Guided Adaptive Radiotherapy Dose-escalation Study (InGReS) – A Phase 1 multicentre feasibility study

•Image-guided adaptive radiotherapy may allow safe dose-escalation to smaller tumour volumes, preserving acceptable toxicity rates.•Intra-treatment MRI and FDG-PET-CT imaging can be used to identify and delineate residual primary tumours for dose-escalation in locally advanced head and neck squamous...

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Veröffentlicht in:	Radiotherapy and oncology 2023-06, Vol.183, p.109645-109645, Article 109645
Hauptverfasser:	Adjogatse, Delali, Michaelidou, Andriana, Sanchez Nieto, Beatriz, Kozarski, Robert, Sassoon, Isabel, Evans, Mererid, Rackley, Thomas, Shah, Simon, Eaton, David, Pike, Lucy, Curry, Sorcha, Gould, Sarah-May, Thomas, Christopher, Kong, Anthony, Petkar, Imran, Reis-Ferreira, Miguel, Connor, Stephen, Barrington, Sally Fiona, Lei, Mary, Guerrero Urbano, Teresa
Format:	Artikel
Sprache:	eng
Schlagworte:	Clinical Trials, Phase I as Topic Feasibility Studies Humans Multicenter Studies as Topic Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted - methods Radiotherapy, Image-Guided - methods Radiotherapy, Intensity-Modulated - methods
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Zusammenfassung:	•Image-guided adaptive radiotherapy may allow safe dose-escalation to smaller tumour volumes, preserving acceptable toxicity rates.•Intra-treatment MRI and FDG-PET-CT imaging can be used to identify and delineate residual primary tumours for dose-escalation in locally advanced head and neck squamous cell carcinoma.•Here we describe a novel multi-institutional phase I study of image-guided adaptive radiotherapy, using both MRI and FDG-PET to guide dose-escalation.
ISSN:	0167-8140 1879-0887
DOI:	10.1016/j.radonc.2023.109645