Monocytes can proliferate in vacant niches before differentiation into macrophages

Monocytes can proliferate in vacant niches before differentiation into macrophages

When an interstitial macrophage niche is empty, classical monocytes can proliferate locally in a manner that is restricted by the transcription factor MAFB, before undergoing differentiation into distinct macrophage subsets. These findings reveal a new function of monocytes and highlight the complex...

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Veröffentlicht in:Nature immunology 2023-05, Vol.24 (5), p.749-750
Format: Artikel
Sprache:eng
Schlagworte:
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Biology
Biomedical and Life Sciences
Biomedicine
Cell cycle
Cell Differentiation
Diphtheria
Flow cytometry
Immunology
Infectious Diseases
Macrophages
Monocytes
Research Briefing
Transcription factors
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Zusammenfassung:When an interstitial macrophage niche is empty, classical monocytes can proliferate locally in a manner that is restricted by the transcription factor MAFB, before undergoing differentiation into distinct macrophage subsets. These findings reveal a new function of monocytes and highlight the complex regulation of proliferation and differentiation during macrophage development.
ISSN:1529-2908
1529-2916
DOI:10.1038/s41590-023-01480-7