Synthesis of fused bis-indazoles/indazoles via a one-pot sequential strategy

We report here an efficient synthesis of fused bis-indazoles/indazoles a one-pot sequential strategy starting from -azido aldehydes and amines. This novel method involves the sequential formation of 2 -indazole followed by a Pd-catalyzed intramolecular cross-dehydrogenative coupling reaction. Overal...

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Veröffentlicht in:Organic & biomolecular chemistry 2023-03, Vol.21 (13), p.2816-2821
Hauptverfasser: Gugulothu, Kishan, Jatoth, Ramanna, Edukondalu, Peramalla, Vanga, Anusha, Matta, Raghavender, Shiva Kumar, K
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Sprache:eng
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Zusammenfassung:We report here an efficient synthesis of fused bis-indazoles/indazoles a one-pot sequential strategy starting from -azido aldehydes and amines. This novel method involves the sequential formation of 2 -indazole followed by a Pd-catalyzed intramolecular cross-dehydrogenative coupling reaction. Overall, this one-pot sequential reaction involved the formation of new five bonds, resulting in the formation of three heterocyclic rings.
ISSN:1477-0520
1477-0539
DOI:10.1039/d3ob00121k