Enantioselective cyanation of propargylic C-H bonds via cooperative photoredox and copper catalysis

Enantioselective cyanation of propargylic C-H bonds via cooperative photoredox and copper catalysis

Herein, we report an enantioselective cyanation of propargylic C-H bonds by combining photoredox catalysis with a copper-catalyzed radical relay in which the propargylic radical was generated by an intramolecular 1,5-HAT process. This reaction provides easy access to optically pure propargyl nitrile...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2023-04, Vol.59 (31), p.4656-4659
Hauptverfasser: Deng, Yunshun, Lu, Ronghua, Chen, Pinhong, Liu, Guosheng
Format: Artikel
Sprache:eng
Schlagworte:
Copper
Enantiomers
Photoredox catalysis
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Zusammenfassung:Herein, we report an enantioselective cyanation of propargylic C-H bonds by combining photoredox catalysis with a copper-catalyzed radical relay in which the propargylic radical was generated by an intramolecular 1,5-HAT process. This reaction provides easy access to optically pure propargyl nitrile compounds under mild conditions.
ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc00410d