Helicobacter pylori, Homologous-Recombination Genes, and Gastric Cancer

Infection with Helicobacter pylori is known to confer a risk of gastric cancer. In this study, persons who carried certain genetic variants and were infected with H. pylori had an excess risk of gastric cancer.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2023-03, Vol.388 (13), p.1181-1190
Hauptverfasser:	Usui, Yoshiaki, Taniyama, Yukari, Endo, Mikiko, Koyanagi, Yuriko N., Kasugai, Yumiko, Oze, Isao, Ito, Hidemi, Imoto, Issei, Tanaka, Tsutomu, Tajika, Masahiro, Niwa, Yasumasa, Iwasaki, Yusuke, Aoi, Tomomi, Hakozaki, Nozomi, Takata, Sadaaki, Suzuki, Kunihiko, Terao, Chikashi, Hatakeyama, Masanori, Hirata, Makoto, Sugano, Kokichi, Yoshida, Teruhiko, Kamatani, Yoichiro, Nakagawa, Hidewaki, Matsuda, Koichi, Murakami, Yoshinori, Spurdle, Amanda B., Matsuo, Keitaro, Momozawa, Yukihide
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenomatous polyposis coli Age Bacterial Infections BRCA1 protein BRCA2 protein Cancer E-cadherin Epidemiology Family medical history Gastric cancer Gastroenterology Gastrointestinal Tract Cancer Genes Genetic Predisposition to Disease - genetics Genetics Genetics General Germ-Line Mutation - genetics Helicobacter Infections - complications Helicobacter Infections - genetics Helicobacter Infections - microbiology Helicobacter pylori Helicobacter pylori - genetics Hematology Homologous recombination Homologous Recombination - genetics Humans Infections Infectious Disease Medical research MLH1 protein MSH2 protein MSH6 protein Oncology Patients Population Risk Factors Software Stomach Neoplasms - etiology Stomach Neoplasms - genetics Surveillance Survival analysis
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Beschreibung
Zusammenfassung:	Infection with Helicobacter pylori is known to confer a risk of gastric cancer. In this study, persons who carried certain genetic variants and were infected with H. pylori had an excess risk of gastric cancer.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2211807