A Fatal Case of Neuroblastoma Complicated by Posterior Reversible Encephalopathy with Rapidly Evolving Transplantation-Associated Thrombotic Microangiopathy

A Fatal Case of Neuroblastoma Complicated by Posterior Reversible Encephalopathy with Rapidly Evolving Transplantation-Associated Thrombotic Microangiopathy

BACKGROUNDTransplantation-associated thrombotic microangiopathy (TA-TMA) is a severe complication of hematopoietic stem cell transplantation and is sometimes fatal. OBSERVATIONSA 4-year-old, male patient with stage M neuroblastoma (NBL) who had received an allogeneic bone marrow transplantation (BMT...

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Veröffentlicht in:Children (Basel, Switzerland) Switzerland), 2023, Vol.10 (3)
Hauptverfasser: Matsui, Motohiro, Makimoto, Atsushi, Saito, Yuya, Enokizono, Mikako, Matsuoka, Kentaro, Yuza, Yuki
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container_issue 3
container_start_page
container_title Children (Basel, Switzerland)
container_volume 10
creator Matsui, Motohiro
Makimoto, Atsushi
Saito, Yuya
Enokizono, Mikako
Matsuoka, Kentaro
Yuza, Yuki
description BACKGROUNDTransplantation-associated thrombotic microangiopathy (TA-TMA) is a severe complication of hematopoietic stem cell transplantation and is sometimes fatal. OBSERVATIONSA 4-year-old, male patient with stage M neuroblastoma (NBL) who had received an allogeneic bone marrow transplantation (BMT) from his sibling five months previously presented with rapidly progressive posterior reversible encephalopathy (PRES) complicated with TA-TMA. Although the patient was transferred to the pediatric intensive care unit, he died within one week after the onset of the latest symptoms. CONCLUSIONSThis is the first description of a fatal case of NBL complicated by PRES with rapidly evolving TA-TMA after an allogenic BMT.
doi_str_mv 10.3390/children10030506
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title A Fatal Case of Neuroblastoma Complicated by Posterior Reversible Encephalopathy with Rapidly Evolving Transplantation-Associated Thrombotic Microangiopathy
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