A Fatal Case of Neuroblastoma Complicated by Posterior Reversible Encephalopathy with Rapidly Evolving Transplantation-Associated Thrombotic Microangiopathy
BACKGROUNDTransplantation-associated thrombotic microangiopathy (TA-TMA) is a severe complication of hematopoietic stem cell transplantation and is sometimes fatal. OBSERVATIONSA 4-year-old, male patient with stage M neuroblastoma (NBL) who had received an allogeneic bone marrow transplantation (BMT...
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Veröffentlicht in: | Children (Basel, Switzerland) Switzerland), 2023, Vol.10 (3) |
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Hauptverfasser: | , , , , , |
Format: | Report |
Sprache: | eng |
Online-Zugang: | Volltext |
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Zusammenfassung: | BACKGROUNDTransplantation-associated thrombotic microangiopathy (TA-TMA) is a severe complication of hematopoietic stem cell transplantation and is sometimes fatal. OBSERVATIONSA 4-year-old, male patient with stage M neuroblastoma (NBL) who had received an allogeneic bone marrow transplantation (BMT) from his sibling five months previously presented with rapidly progressive posterior reversible encephalopathy (PRES) complicated with TA-TMA. Although the patient was transferred to the pediatric intensive care unit, he died within one week after the onset of the latest symptoms. CONCLUSIONSThis is the first description of a fatal case of NBL complicated by PRES with rapidly evolving TA-TMA after an allogenic BMT. |
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ISSN: | 2227-9067 2227-9067 |
DOI: | 10.3390/children10030506 |