Perovskite‐Type Manganese Vanadate Sonosensitizers with Biodegradability for Enhanced Sonodynamic Therapy of Cancer

Sonodynamic therapy (SDT) has attracted intensive attention, but is still hindered by low sonosensitization and non‐biodegradability of the traditional sonosensitizers. Herein, perovskite‐type manganese vanadate (MnVO3) sonosensitizers integrating high reactive oxide species (ROS) production efficiency and appropriate bio‐degradability are developed for enhanced SDT. Taking advantage of the intrinsic properties of perovskites such as narrow bandgap and substantial oxygen vacancies, MnVO3 shows a facile ultrasound (US)‐triggered electrons‐holes separation and restrained recombination, thus enhancing the ROS quantum yield in SDT. Furthermore, MnVO3 exhibits a considerable chemodynamic therapy (CDT) effect under the acidic condition probably owing to the presence of manganese and vanadium ions. Due to the presence of high‐valent vanadium, MnVO3 can also eliminate glutathione (GSH) within the tumor microenvironment, which synergistically amplifies the efficacy of SDT and CDT. Importantly, the perovskite structure bestows MnVO3 with superior biodegradability, which alleviates the long‐term presence of residues in metabolic organs after therapeutic actions. Based on these characteristics, US‐assisted MnVO3 achieves an excellent antitumor outcome along with low systemic toxicity. Overall, perovskite‐type MnVO3 may be promising sonosensitizers for highly efficient and safe treatment of cancer. The work attempts to explore the potential utility of perovskites in the design of degradable sonosensitizers. Perovskite‐type manganese vanadate (MnVO3) nanoparticles are designed as biodegradable sonosensitizers for enhanced sonodynamic therapy. Due to the inherent properties of perovskites with narrow bandgap and oxygen vacancies, MnVO3 exhibits a facilely sono‐triggered electrons‐holes separation and restrained recombination. The decomposition property of perovskite structure bestows the sonosensitizers with superior biodegradability, which is favorable for fast clearance without long‐term toxicity.