The mechanosensor Piezo1 rings the alarm on epithelial intruders

Recognition of invasive pathogens by the epithelium that is constantly exposed to microbial products remains incompletely understood. In a recent study, Tadala et al. demonstrated that the entry process of intracellular bacteria is itself a mechanical signal that is detected by the stretch-activated...

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Veröffentlicht in:	Trends in biochemical sciences (Amsterdam. Regular ed.) 2023-06, Vol.48 (6), p.500-502
Hauptverfasser:	Giron-Ceron, Diana, Jaumouillé, Valentin
Format:	Artikel
Sprache:	eng
Schlagworte:	inflammation intracellular pathogens Ion Channels - metabolism mechanotransduction Mechanotransduction, Cellular membrane ruffles mucosal immunity Piezo1 Signal Transduction
Online-Zugang:	Volltext
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