The mechanosensor Piezo1 rings the alarm on epithelial intruders

The mechanosensor Piezo1 rings the alarm on epithelial intruders

Recognition of invasive pathogens by the epithelium that is constantly exposed to microbial products remains incompletely understood. In a recent study, Tadala et al. demonstrated that the entry process of intracellular bacteria is itself a mechanical signal that is detected by the stretch-activated...

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Veröffentlicht in:Trends in biochemical sciences (Amsterdam. Regular ed.) 2023-06, Vol.48 (6), p.500-502
Hauptverfasser: Giron-Ceron, Diana, Jaumouillé, Valentin
Format: Artikel
Sprache:eng
Schlagworte:
inflammation
intracellular pathogens
Ion Channels - metabolism
mechanotransduction
Mechanotransduction, Cellular
membrane ruffles
mucosal immunity
Piezo1
Signal Transduction
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Zusammenfassung:Recognition of invasive pathogens by the epithelium that is constantly exposed to microbial products remains incompletely understood. In a recent study, Tadala et al. demonstrated that the entry process of intracellular bacteria is itself a mechanical signal that is detected by the stretch-activated channel Piezo1, which triggers innate immune signaling.
ISSN:0968-0004
1362-4326
DOI:10.1016/j.tibs.2023.03.001