The mechanosensor Piezo1 rings the alarm on epithelial intruders
Recognition of invasive pathogens by the epithelium that is constantly exposed to microbial products remains incompletely understood. In a recent study, Tadala et al. demonstrated that the entry process of intracellular bacteria is itself a mechanical signal that is detected by the stretch-activated...
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| Veröffentlicht in: | Trends in biochemical sciences (Amsterdam. Regular ed.) 2023-06, Vol.48 (6), p.500-502 |
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| container_title | Trends in biochemical sciences (Amsterdam. Regular ed.) |
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| creator | Giron-Ceron, Diana Jaumouillé, Valentin |
| description | Recognition of invasive pathogens by the epithelium that is constantly exposed to microbial products remains incompletely understood. In a recent study, Tadala et al. demonstrated that the entry process of intracellular bacteria is itself a mechanical signal that is detected by the stretch-activated channel Piezo1, which triggers innate immune signaling. |
| doi_str_mv | 10.1016/j.tibs.2023.03.001 |
| format | Article |
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| ispartof | Trends in biochemical sciences (Amsterdam. Regular ed.), 2023-06, Vol.48 (6), p.500-502 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | inflammation intracellular pathogens Ion Channels - metabolism mechanotransduction Mechanotransduction, Cellular membrane ruffles mucosal immunity Piezo1 Signal Transduction |
| title | The mechanosensor Piezo1 rings the alarm on epithelial intruders |
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