Trends and in‐hospital cardiac complications in patients with atrial fibrillation undergoing allogeneic stem cell transplant: A National Inpatient Sample analysis (2002–2019)
Background Cardiovascular comorbidities increase the risk of transplant‐associated complications. However, the impact of atrial fibrillation (AF) as an independent risk factor remains limited. Methods The National Inpatient Sample (NIS) database was queried using the International Classification of...
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| Veröffentlicht in: | European journal of haematology 2023-06, Vol.110 (6), p.754-761 |
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| creator | Ammad Ud Din, Mohammad Chowdhury, Medhat Shahzad, Moazzam Zahid, Salman Liaqat, Hania Osama, Muhammad Elmariah, Hany |
| description | Background
Cardiovascular comorbidities increase the risk of transplant‐associated complications. However, the impact of atrial fibrillation (AF) as an independent risk factor remains limited.
Methods
The National Inpatient Sample (NIS) database was queried using the International Classification of Diseases codes to identify patients admitted for allogeneic stem cell transplant (ASCT). The patients were then subclassified into with and without AF. Subsequently, a multivariate logistic regression model was constructed to account for patient demographics, comorbidities, and hospital characteristics to evaluate the impact of AF on the primary outcome of interest: all‐cause mortality, and secondary outcomes of interest that included common hospitalization complications.
Results
The data for 77 157 cases of ASCT were collected between 2002 and 2019. Among these 5086 (6.6%) cases had concurrent AF. Multivariate logistic regression revealed patients undergoing ASCT with AF had almost a three times higher risk of all‐cause mortality (odds ratio = 2.99 [95% confidence interval: 2.73–3.28]; p |
| doi_str_mv | 10.1111/ejh.13960 |
| format | Article |
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Cardiovascular comorbidities increase the risk of transplant‐associated complications. However, the impact of atrial fibrillation (AF) as an independent risk factor remains limited.
Methods
The National Inpatient Sample (NIS) database was queried using the International Classification of Diseases codes to identify patients admitted for allogeneic stem cell transplant (ASCT). The patients were then subclassified into with and without AF. Subsequently, a multivariate logistic regression model was constructed to account for patient demographics, comorbidities, and hospital characteristics to evaluate the impact of AF on the primary outcome of interest: all‐cause mortality, and secondary outcomes of interest that included common hospitalization complications.
Results
The data for 77 157 cases of ASCT were collected between 2002 and 2019. Among these 5086 (6.6%) cases had concurrent AF. Multivariate logistic regression revealed patients undergoing ASCT with AF had almost a three times higher risk of all‐cause mortality (odds ratio = 2.99 [95% confidence interval: 2.73–3.28]; p < .01). AF patients also had a higher risk for cardiac arrest, cardiogenic shock, acute kidney injury, and need for hemodialysis (all p < .01).
Conclusion
AF causes a higher risk of death and cardiovascular complications among patients undergoing ASCT. This signifies the importance of pretransplant consultation and optimization for cardiovascular comorbidities to improve hospitalization outcomes.</description><identifier>ISSN: 0902-4441</identifier><identifier>EISSN: 1600-0609</identifier><identifier>DOI: 10.1111/ejh.13960</identifier><identifier>PMID: 36949272</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>allogeneic stem cell transplant ; Allografts ; atrial fibrillation ; Atrial Fibrillation - complications ; Atrial Fibrillation - diagnosis ; Atrial Fibrillation - epidemiology ; Cardiac arrhythmia ; cardiooncology ; Cardiovascular diseases ; Comorbidity ; Fibrillation ; Hematopoietic Stem Cell Transplantation - adverse effects ; Hemodialysis ; Hospitals ; Humans ; Inpatients ; Mortality ; Regression analysis ; Risk Factors ; Stem Cell Transplantation</subject><ispartof>European journal of haematology, 2023-06, Vol.110 (6), p.754-761</ispartof><rights>2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3530-fabeed9164871209a2c3ee1bdfdca6db8c35445516ccc4fcae285c39174fe82f3</citedby><cites>FETCH-LOGICAL-c3530-fabeed9164871209a2c3ee1bdfdca6db8c35445516ccc4fcae285c39174fe82f3</cites><orcidid>0000-0001-9083-636X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fejh.13960$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fejh.13960$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36949272$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ammad Ud Din, Mohammad</creatorcontrib><creatorcontrib>Chowdhury, Medhat</creatorcontrib><creatorcontrib>Shahzad, Moazzam</creatorcontrib><creatorcontrib>Zahid, Salman</creatorcontrib><creatorcontrib>Liaqat, Hania</creatorcontrib><creatorcontrib>Osama, Muhammad</creatorcontrib><creatorcontrib>Elmariah, Hany</creatorcontrib><title>Trends and in‐hospital cardiac complications in patients with atrial fibrillation undergoing allogeneic stem cell transplant: A National Inpatient Sample analysis (2002–2019)</title><title>European journal of haematology</title><addtitle>Eur J Haematol</addtitle><description>Background
Cardiovascular comorbidities increase the risk of transplant‐associated complications. However, the impact of atrial fibrillation (AF) as an independent risk factor remains limited.
Methods
The National Inpatient Sample (NIS) database was queried using the International Classification of Diseases codes to identify patients admitted for allogeneic stem cell transplant (ASCT). The patients were then subclassified into with and without AF. Subsequently, a multivariate logistic regression model was constructed to account for patient demographics, comorbidities, and hospital characteristics to evaluate the impact of AF on the primary outcome of interest: all‐cause mortality, and secondary outcomes of interest that included common hospitalization complications.
Results
The data for 77 157 cases of ASCT were collected between 2002 and 2019. Among these 5086 (6.6%) cases had concurrent AF. Multivariate logistic regression revealed patients undergoing ASCT with AF had almost a three times higher risk of all‐cause mortality (odds ratio = 2.99 [95% confidence interval: 2.73–3.28]; p < .01). AF patients also had a higher risk for cardiac arrest, cardiogenic shock, acute kidney injury, and need for hemodialysis (all p < .01).
Conclusion
AF causes a higher risk of death and cardiovascular complications among patients undergoing ASCT. This signifies the importance of pretransplant consultation and optimization for cardiovascular comorbidities to improve hospitalization outcomes.</description><subject>allogeneic stem cell transplant</subject><subject>Allografts</subject><subject>atrial fibrillation</subject><subject>Atrial Fibrillation - complications</subject><subject>Atrial Fibrillation - diagnosis</subject><subject>Atrial Fibrillation - epidemiology</subject><subject>Cardiac arrhythmia</subject><subject>cardiooncology</subject><subject>Cardiovascular diseases</subject><subject>Comorbidity</subject><subject>Fibrillation</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Hemodialysis</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Inpatients</subject><subject>Mortality</subject><subject>Regression analysis</subject><subject>Risk Factors</subject><subject>Stem Cell Transplantation</subject><issn>0902-4441</issn><issn>1600-0609</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUFO3DAUhi3UCqbQRS9QWeoGFgHbcTJxdwhRoELtArqOHPtlxiPHTm1HaHYcAak36ZE4CWZm2kWlemMvPn_v1_sR-kDJKc3nDFbLU1qKmuyhGa0JKUhNxBs0I4KwgnNOD9C7GFeEECbofB8dlLXggs3ZDP2-D-B0xNJpbNzz49PSx9EkabGSQRupsPLDaI2SyXgXM4PH_ASXIn4waYllCibTvemCsXZD4clpCAtv3AJLa_0CHBiFY4IBK7AWpyBdHK106TM-x982n7Ljxu3U-E7mmZBDSbuOJuJjlqM_P_5ihIqTI_S2lzbC-919iH58uby_uC5uv1_dXJzfFqqsSlL0sgPQgta8mVNGhGSqBKCd7rWSte6ajHFeVbRWSvFeSWBNpcq8IN5Dw_ryEB1vvWPwPyeIqR1MfM0vHfgptmwuCKlow-uMfvoHXfkp5PSZakjDqciDMnWypVTwMQbo2zGYQYZ1S0n7WmSbi2w3RWb24844dQPov-Sf5jJwtgUejIX1_03t5dfrrfIFTuur2A</recordid><startdate>202306</startdate><enddate>202306</enddate><creator>Ammad Ud Din, Mohammad</creator><creator>Chowdhury, Medhat</creator><creator>Shahzad, Moazzam</creator><creator>Zahid, Salman</creator><creator>Liaqat, Hania</creator><creator>Osama, Muhammad</creator><creator>Elmariah, Hany</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9083-636X</orcidid></search><sort><creationdate>202306</creationdate><title>Trends and in‐hospital cardiac complications in patients with atrial fibrillation undergoing allogeneic stem cell transplant: A National Inpatient Sample analysis (2002–2019)</title><author>Ammad Ud Din, Mohammad ; Chowdhury, Medhat ; Shahzad, Moazzam ; Zahid, Salman ; Liaqat, Hania ; Osama, Muhammad ; Elmariah, Hany</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3530-fabeed9164871209a2c3ee1bdfdca6db8c35445516ccc4fcae285c39174fe82f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>allogeneic stem cell transplant</topic><topic>Allografts</topic><topic>atrial fibrillation</topic><topic>Atrial Fibrillation - complications</topic><topic>Atrial Fibrillation - diagnosis</topic><topic>Atrial Fibrillation - epidemiology</topic><topic>Cardiac arrhythmia</topic><topic>cardiooncology</topic><topic>Cardiovascular diseases</topic><topic>Comorbidity</topic><topic>Fibrillation</topic><topic>Hematopoietic Stem Cell Transplantation - adverse effects</topic><topic>Hemodialysis</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Inpatients</topic><topic>Mortality</topic><topic>Regression analysis</topic><topic>Risk Factors</topic><topic>Stem Cell Transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ammad Ud Din, Mohammad</creatorcontrib><creatorcontrib>Chowdhury, Medhat</creatorcontrib><creatorcontrib>Shahzad, Moazzam</creatorcontrib><creatorcontrib>Zahid, Salman</creatorcontrib><creatorcontrib>Liaqat, Hania</creatorcontrib><creatorcontrib>Osama, Muhammad</creatorcontrib><creatorcontrib>Elmariah, Hany</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ammad Ud Din, Mohammad</au><au>Chowdhury, Medhat</au><au>Shahzad, Moazzam</au><au>Zahid, Salman</au><au>Liaqat, Hania</au><au>Osama, Muhammad</au><au>Elmariah, Hany</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trends and in‐hospital cardiac complications in patients with atrial fibrillation undergoing allogeneic stem cell transplant: A National Inpatient Sample analysis (2002–2019)</atitle><jtitle>European journal of haematology</jtitle><addtitle>Eur J Haematol</addtitle><date>2023-06</date><risdate>2023</risdate><volume>110</volume><issue>6</issue><spage>754</spage><epage>761</epage><pages>754-761</pages><issn>0902-4441</issn><eissn>1600-0609</eissn><abstract>Background
Cardiovascular comorbidities increase the risk of transplant‐associated complications. However, the impact of atrial fibrillation (AF) as an independent risk factor remains limited.
Methods
The National Inpatient Sample (NIS) database was queried using the International Classification of Diseases codes to identify patients admitted for allogeneic stem cell transplant (ASCT). The patients were then subclassified into with and without AF. Subsequently, a multivariate logistic regression model was constructed to account for patient demographics, comorbidities, and hospital characteristics to evaluate the impact of AF on the primary outcome of interest: all‐cause mortality, and secondary outcomes of interest that included common hospitalization complications.
Results
The data for 77 157 cases of ASCT were collected between 2002 and 2019. Among these 5086 (6.6%) cases had concurrent AF. Multivariate logistic regression revealed patients undergoing ASCT with AF had almost a three times higher risk of all‐cause mortality (odds ratio = 2.99 [95% confidence interval: 2.73–3.28]; p < .01). AF patients also had a higher risk for cardiac arrest, cardiogenic shock, acute kidney injury, and need for hemodialysis (all p < .01).
Conclusion
AF causes a higher risk of death and cardiovascular complications among patients undergoing ASCT. This signifies the importance of pretransplant consultation and optimization for cardiovascular comorbidities to improve hospitalization outcomes.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36949272</pmid><doi>10.1111/ejh.13960</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-9083-636X</orcidid></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | allogeneic stem cell transplant Allografts atrial fibrillation Atrial Fibrillation - complications Atrial Fibrillation - diagnosis Atrial Fibrillation - epidemiology Cardiac arrhythmia cardiooncology Cardiovascular diseases Comorbidity Fibrillation Hematopoietic Stem Cell Transplantation - adverse effects Hemodialysis Hospitals Humans Inpatients Mortality Regression analysis Risk Factors Stem Cell Transplantation |
| title | Trends and in‐hospital cardiac complications in patients with atrial fibrillation undergoing allogeneic stem cell transplant: A National Inpatient Sample analysis (2002–2019) |
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